Herbal Ashwagandha Kills Off Kidney Cancer Cells in Vitro

By Kyle J. Norton

Cancer, a class of diseases refers to a group of cells that grow and multiply disorderly and uncontrollably in a specific tissue of an organ.

Over time, after successfully penetrating to the deeper layers of the organs, most cancer can travel a distance away to damage other healthy tissues via lymph or blood, leading to secondary metastasis.

The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine and formed part of the detoxified organs to filter out blood by removing wastes and extra water to make urine.

Kidney cancer is a medical condition associated with cell growth irregularly that starts in the cells on the surface of the inner lining of the kidney tissue, before spreading to the deeper layers to form a tumor through unlimited cell cycle division.

According to the statistics provided by the American Cancer Society, kidney cancer is among the 10 most common cancers in both men and women in the US. In 2019, approximately, 73,820 new cases of kidney cancer will be diagnosed including 44,120 in men and 29,700 in women. The disease also causes the death of 14,770 Americans, including 9,820 men and 4,950 women in the same year.

The causes of kidney cancer are unknown. However, epidemiologically, the increase in age, gender, smoking, obesity, family diabetes, long-term exposure to chemical toxins, and use of diuretic and nondiuretic anti-hypertensive medication are some prevalent factors found in patients with kidney cancer.

Some researchers suggested the increased incidence of kidney cancer in the US may correlate to obesity caused by the promotion of a high-fat diet over the past decades. 

Dr. Wilson KM, the lead scientist in the joint study led by the Chan School of Public Health wrote, "Obesity has been largely measured as body mass index (BMI). Studies which evaluated other measures of obesity including waist circumference (WC), waist-to-hip ratio (WHR) as well as an increase in weight have reported similar positive associations with RCC".

And " Although the mechanisms by which obesity influences renal carcinogenesis have been under-explored, insulin resistance and certain growth factors including insulin-like growth factor (IGF-1), sex steroid hormones, and biochemical markers such as adiponectin may be involved".

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound which process renal protective activity, researchers examined the effects of Withaferin A, a major chemical constituent of Withania somnifera, in the renal cancer cell line.

According to tested analysis, withaferin A application resulted in apoptotic cell death in several types of human renal cancer cells in a dose-dependent manner.

Furthermore, withaferin A inhibited the Caki cells by inducing signature endoplasmic reticulum (ER) stress markers, leading to the accumulation of unfolded proteins associated with cancer cell death.

Moreover, CAAT/enhancer-binding protein-homologous protein (CHOP) associated with pro-apoptotic function in the integrated stress response was elevated by the injection of withaferin A.

Intertestingly, withaferin A-induced ER stress to cause cytotoxicity against renal cancer cells by increasing levels of reactive oxygen species (ROS).

Based on the findings, researchers said, "the present study provides strong evidence supporting an important role of the ER stress response in mediating withaferin A-induced apoptosis".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of renal cancer, pending to the confirmation of large sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells by Choi MJ1, Park EJ, Min KJ, Park JW, Kwon TK. (PubMed)
(2) Obesity and Kidney Cancer by Wilson KM1,2, Cho E. (PubMed)