Phytochemical 3,3'-Diindolylmethane Speeds Up Wound Healing

By Kyle J. Norton


Wound healing is a natural process to repair the wound or cut through a number of stages.

In the first stage, after receiving the message from the central nervous system, the immune first  line of defense white blood cells stimulate the production of blood palettes to the site of damage to cover the wound and activate the protein associated with the production of pro-inflammatory cytokines to fight off the micro pathogens trying to enter the body.

Under normal condition, proteins associated with the production of anti-inflammation cytokines may also switch to proinflammatory cytokines, depending on the size and location of the wound.

Overproduction of pro-inflammatory cytokines in this phase can cause the death of nearby healthy cells, leading to the formation of a scar.

Most microbial invaders are stopped at the acute phase of infection.

The wound healing process is divided into four overlapping phases: hemostasis, inflammatory, proliferative, and maturation.

Any interruption of the stage of wound healing also can lead to imbalanced production and dissolving of collagens in the site, inducing the formation of scars.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.

In the urgency of finding a natural compound for speed-up wound healing without side effects, researchers evaluated 3,3'-diindolylmethane (DIM), a natural small-molecule compound involved in the repairing effects of hucMSCs on a deep second-degree burn injury rat model.

Where human umbilical cord-derived mesenchymal stem cells (hucMSCs) has been used in the laboratory as a promising therapeutic tool in regenerative medicine.

HucMSCs pretreatment of 50 μM of DIM exhibited desirable repairing effects compared to the untreated hucMSCs.

In vivo, DIM enhanced hucMSCs in tissue regeneration by activation of proteins that pass signals into a cell through cell surface receptors.

Furthermore, DIM-primed hucMSCs (DIM-hucMSCs) also promotes tissue regeneration by suppressing the inhibition of β-catenin that impairs the healing effects.

Moreover, DIM promoted the Wnt11 expression associated with all regeneration stages in hucMSC-derived exosomes.

Decreased expression of  Wnt11 showed to inhibited β-catenin activation.

Based on the findings, DIM enhanced tissue regeneration after wound by promoting the genes associated with the healing process.

Dr. Shi H the lead scientist said, "DIM promotes the stemness of hucMSCs through increased exosomal Wnt11 autocrine signaling, which provides a novel strategy for improving the therapeutic effects of hucMSCs on wound healing".

Taken altogether, 3,3'-Diindolylmethane derived from the indole-3-carbinol may be considered a supplement for speed-up wound healing, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane stimulates exosomal Wnt11 autocrine signaling in human umbilical cord mesenchymal stem cells to enhance wound healing by Shi H1, Xu X1, Zhang B1, Xu J1, Pan Z1, Gong A1, Zhang X1, Li R1, Sun Y1, Yan Y1, Mao F1, Qian H1, Xu W. (PubMed)