Healthy Food Onion Block Cancer Cells Proliferation

By Kyle J. Norton

Proliferation is a process of cancer growth associated with an abnormally high rate of cancer cells division, leading to rapid overgrowth of the tumor.

Cancer is a  class of medical condition caused by irregular cell growth that starts in the cell on the surface of the inner lining tissue in a specific organ.

Most cancers that grow in size through proliferation can be invasive. In other words, after passing the stages of colonizing the entire tissues of the organ, invasive cancer cells can travel a distance away from the primary site in infect other healthy tissue and organ via blood and fluid circulation, leading to secondary metastasis.

Cancer cell proliferation by dividing unlimitedly, compared to normal cells that die after a certain cell cycle division.

More precisely,
* The growth of normal cells
Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell grow to replace millions of dead cells and to keep our body in balance and healthy.
Sometimes, acceleration of cells growth is necessary to prevent further damage to the body organ, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors. Unfortunately, skin cells sometimes overgrow while healing, leading to scar to the skin.

*The primary tumor; size and growth
A primary tumor or original tumor that the tumor progression that yields a cancerous mass. Some cancers can begin in several places, such as lymphomas and leukemias. Most cancers can not be detected until they formed a small grape-like lump. Cancer cells need 42 doublings before it can produce enough cancer cells to cause death.

According to the statistics provided by the National Cancer Institute, In 2018, approximately 1,735,350 cases of cancer were diagnosed in the US and the disease also caused the death of 609,640 Americans.

Epidemiologically, the odds of cancer incidence is 439.2 per 100,000 men and women per year based on 2011–2015 statistics.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of cancer, researchers examined the effects of ethyl acetate extract of onion (EEO) had potent inhibitory effects on FAS gene involved in the over-expressing human breast cancer MDA-MB-231 cells.

According to the tested analysis, EEO exhibited MDA-MB-231 cells. apoptosis through the inhibition of FAS, the apoptosis antigen.

Furthermore, according to the differentiation of 3T3-L1 adipocytes used in vitro model of white adipocytes, EEO also suppressed the lipid accumulation via inhibition of FAS, a condition found in obese patients.

These results strongly suggested that EEO not only prevents the risk of breast cancer in obese but also has a strong impact on the reduced risk of other types of cancer associated with the FAS gene.

Dr. Wang Y, the lead scientist wrote in the final report, "Since obesity is closely related to breast cancer and obese patients are at elevated risk of developing various cancers, these findings suggested that onion might be useful for preventing obesity-related malignancy".

Additionally, in the examination of the anticancer effects on five onion varieties grown in Ontario against human adenocarcinoma (Caco-2) cells, the University of Chinese Academy of Sciences suggested
* Onion extracts and pure extracts of flavonoids exhibit antiproliferative effects against the tested cancer cell through its major phytochemical quercetin, myricetin, and kaempferol.

* Onion varieties also exhibited antiproliferative activity similar to purified flavonoids, according to the lactate dehydrogenase (LDH) assays.

* The Safrane extracts showed the weakest antiproliferative activity compared to other variety.

Taken altogether, onion may be considered a remedy for the prevention and treatment of cancer via antiproliferative activity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Inhibitory effects of onion (Allium cepa L.) extract on proliferation of cancer cells and adipocytes via inhibiting fatty acid synthase by Wang Y1, Tian WX, Ma XF. (PubMed)
(2) Antiproliferative activity of Ontario grown onions against colorectal adenocarcinoma cells by Murayyan AI1, Manohar CM1, Hayward G2, Neethirajan S. (PubMed)