Monday, 15 July 2019

Healthy Food Onion Protects the Cell DNA Against the Risk of Ovarian Cancer

By Kyle J. Norton

Cancer is a class of diseases caused by irregular cells growth due to the alternation of the DNA.

After penetrating into deeper layer tissues of a specific organ, the proliferative tumor cell can travel a distance away from the originated site to invade other healthy tissues, via lymph or blood.

Most advanced stage of cancer may result in the death of the patients.

The ovaries are an oval-shaped ovum-producing reproductive organ in part of a woman's reproductive system connected to the fallopian tubes and attached to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary take a turn to release an egg every month.

Ovarian cancer is a condition of abnormal cells growth of ovarian cells that start in the cells on the surface of the inner lining tissue of the ovary have become cancerous. Ovarian cancer is one of the most common cancer in the US, according to the statistics adapted from the American Cancer Society's publication,.

 Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.




The exact causes of ovarian cancer are unknown. However, the most common prevalent factors associated with increased risk of ovarian cancer are
*Age
The risk of ovarian cancer increases for women between 50 to 70 years of age.

* Genetic preposition
Women who carry certain mutation genes such as BRCA1 and BRCA2 account for 5%–13% of ovarian cancers.

* Family history
Risk of the disease increases, if one of your direct member family has a history of cancer.

* Never pregnant
Researchers found that the risk of ovarian cancer is lower with numbers of pregnancy.

* Race
White women are associated with a higher risk than other race.

* Hormone therapy
Risk of ovarian cancer increase with the use of hormone replacement therapy in post-menopausal women.

* Chemicalsexposures
Certain chemicals such as asbestos also increase the risk of ovarian cancer.

* High fat dietary
Researchers found that women who diet high in saturated fat and trans fat are at higher risk.

* Fertility medication
Drugs used to enhance fertility such as Clomiphene citrate may increase the risk of ovarian cancer.

* Milk
According to the BBC, researchers found that women who drank two or more glasses a day were at double the risk of those who did not consume it at all, or only in small amounts.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of lung cancer,  researchers examined the effects of onionin A (ONA) derived from the onion in the inhibition of tumor-associated macrophages (TAMs) in the M2 phenotype.

According to the tested analysis.
* Onionin A (ONA )inhibits ovarian cancer cell proliferation induced by co-culture with human macrophages.

* Onionin A directly suppressed lung cancer cell proliferation.

* Onionin A enhanced the effects of anti-cancer drugs was also observed.

* In ovarian cancer cells. signal transducer and activator of transcription 3 (STAT3) involved in cell proliferation and chemo-resistance were significantly suppressed by ONA.

* Additionally, ONA inhibited cancer progression and prolonged the survival time in a murine ovarian cancer model under single and combined with chemo drug treatment conditions.


Based on the finding, researchers said, "ONA is considered useful for the additional treatment of patients with lung cancer owing to its suppression of the pro-tumor activation of tumor-associated macrophages (TAMs) and direct cytotoxicity against cancer cells".

Taken altogether, onion processed a higher mount of onionin A (ONA) may be considered a remedy for the prevention and treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.



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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages by Tsuboki J1,2, Fujiwara Y1, Horlad H1, Shiraishi D1, Nohara T3, Tayama S2, Motohara T2, Saito Y1, Ikeda T3, Takaishi K2, Tashiro H4, Yonemoto Y5, Katabuchi H2, Takeya M1, Komohara Y. (PubMed)
(2) Lung Cancer by Kyle J. Norton

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