Onion, the Natural Anti Ovarian Cancer Functional Food

By Kyle J. Norton

Cancer is the class of chronic disease caused by irregular cell growth in the tissue or specific organ in the body due to the alternation of cell DNA.

The ovaries are oval-shaped ovum-producing reproductive organ formed part of women reproductive system that connects to the fallopian tubes and attaches to the outer layer of the uterus via the ovarian ligament. Usually, the left and right ovary take a turn to release an egg every month.

Ovarian cancer is medical a condition characterized by abnormal cells growth of ovarian cells that start on the surface of the inner lining of the ovary. Over time, the oversize tumor can travel a distance away to infect the nearby organ and tissue via the fluid and blood circulation.

According to the statistics, ovarian cancer is one of the fifth most common cancer, accounting for more deaths than any other cancer of the female reproductive system in the US. 

The lifetime risk of getting ovarian cancer is a woman is about 1 in 78.comapred to the lifetime of dying from ovarian cancer risk of 1 in 108.

Primary ovarian cancer can be classified into

* Epithelial Ovarian Cancer
The epithelial ovarian tumor is a type of cancer arisen from the cell on the surface of the ovary. Epithelial ovarian tumor is the most common form of ovarian cancer accounts for over 90% of ovarian cancer of all cases, including serious tumor, endometrioid tumor, and mucinous cystadenocarcinoma.

* Germ cell ovarian cancer
 Germ cell ovarian tumor is a censer of the egg-producing cells within the ovary. Most germ cell ovarian cancer occur in children and teens as a result of birth defects.

*Sex cord-stromal ovarian cancer
Sex cord-stromal ovarian tumor is cancer arisen from the cell on the tissue of the ovary accounted for 8% of ovarian cancers. Most cases of sex cord-stromal ovarian cancer are found in the older age group.  

The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

On finding a potential compound for the treatment of ovarian cancer, researchers examined whether 

Onionin (ONA) had a therapeutic anti-ovarian cancer effect using in vitro and in vivo.

According to the tested assays,

* ONA reduced the extent of ovarian cancer cell proliferation induced by co-culture with human macrophages.

* Furthermore, ONA also directly suppressed cancer cell proliferation.

* In combined with anti-cancer drugs, ONA significantly improve the efficacy of the drug involved in cell proliferation and chemoresistance in ovarian cancer cells.

* Moreover, the administration of ONA also suppressed ovarian cancer progression and prolonged the survival time in a murine model under single and combined treatment conditions.

Based on the findings, researchers said, "ONA is considered useful for the additional treatment of patients with ovarian cancer owing to its suppression of the pro-tumor activation of TAMs and direct cytotoxicity against cancer cells".

Taken altogether, onion processed abundantly Onionin (ONA) may be considered a remedy for the prevention and treatment of ovarian cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages by Tsuboki J1,2, Fujiwara Y1, Horlad H1, Shiraishi D1, Nohara T3, Tayama S2, Motohara T2, Saito Y1, Ikeda T3, Takaishi K2, Tashiro H4, Yonemoto Y5, Katabuchi H2, Takeya M1, Komohara Y. (PubMed)
(2) Ovarian Cancer - Epithelial Ovarian Cancer by Kyle J. Norton