By Kyle J. Norton
Cytotoxicity is the process in the induction of cell death through toxins.
In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.
Cytotoxicity is the process in the induction of cell death through toxins.
In other words, cell cytotoxicity is the process to use certain chemicals or mediator cells to destroy living cells.
In normal, cytotoxicity can cause the death of healthy cells
In cancers, cytotoxicity can be benefits to human by destroying the cancer cells and prevent them from proliferation.
For example, cytotoxicity induced by oxidative stress due to the imbalanced ratio of free radicals and antioxidant enzymes produced by the body can cause protein, lipid and cellular damage that leads to chronic low-grade inflammatory diseases and cancer.
However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
However, stimulation of ROS and antioxidants production to induce cytotoxicity to the tumors can also cause cancer cell death without damage to nearby healthy cells.
And, " quercetin-induced cytotoxicity in leukemic cells in a dose-dependent manner, while ellagic acid showed only limited toxicity. Besides leukemic cells, quercetin also induced cytotoxicity in breast cancer cells, however, its effect on normal cells was limited or none".
Scientifically, most cases of cancer cells cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.
Furthermore, in the study to assess different varieties of tomato seed extracts potential antioxidant and/or antiproliferative activity, researchers found that San Marzano Rosso seed extract displays the highest free radical-scavenging activity with 68% of 2,2-Diphenyl-1-picrylhydrazyl radical inhibition.
Moreover, according to the brine shrimp test (LD50: 23,198 ppm), San Marzano Rosso seed extract also demonstrated the highest cytotoxicity against A375 cell line, compared to other variety.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells by Figueiredo-González M1, Valentão P1, Pereira DM1, Andrade PB. (PubMed)
(2) Antioxidant and cytotoxic activities investigation of tomato seed extracts by Tommonaro G1, Caporale A, De Martino L, Popolo A, De Prisco R, Nicolaus B, Abbamondi GR, Saturnino C. (PubMed)
(3) Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell. Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis by Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary & Sathees C. Raghavan. (Scientific Report)
Scientifically, most cases of cancer cells cytotoxicity are associated with the stimulation of protein and pathways involved in either gene suppression or cell death programming.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to find a natural ingredient that kills cancer without inducing adverse effects, researchers examined the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of the tomato plant.
Both HME and AcE extracts showed a significant effect in scavenging •NO (IC50 values ranged from 0.87 ± 0.12 to 1.54 ± 0.23 and from 0.90 ± 0.01 to 2.23 ± 0.14 mg mL-1, respectively), compared to HMEs that only scavenge O2•- showing IC50 values from 0.12 ± ≤0.01 to 0.43 ± 0.08 mg mL-1.
and often in the greenhouse.
In the urgency to find a natural ingredient that kills cancer without inducing adverse effects, researchers examined the toxicity against human gastric adenocarcinoma cells (AGS) and the antioxidant activity of hydromethanol (HME), acetone (AcE) and alkaloid (AE) extracts prepared from the leaves of the tomato plant.
Both HME and AcE extracts showed a significant effect in scavenging •NO (IC50 values ranged from 0.87 ± 0.12 to 1.54 ± 0.23 and from 0.90 ± 0.01 to 2.23 ± 0.14 mg mL-1, respectively), compared to HMEs that only scavenge O2•- showing IC50 values from 0.12 ± ≤0.01 to 0.43 ± 0.08 mg mL-1.
In other words, tomato extracts demonstrated a strong effect against human gastric adenocarcinoma cells (AGS) through its cytotoxicity without causing harm to normal cells through the antioxidant activity.
Taken altogether, tomato and its leaves may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of tomato in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Further insights on tomato plant: Cytotoxic and antioxidant activity of leaf extracts in human gastric cells by Figueiredo-González M1, Valentão P1, Pereira DM1, Andrade PB. (PubMed)
(2) Antioxidant and cytotoxic activities investigation of tomato seed extracts by Tommonaro G1, Caporale A, De Martino L, Popolo A, De Prisco R, Nicolaus B, Abbamondi GR, Saturnino C. (PubMed)
(3) Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell. Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis by Shikha Srivastava, Ranganatha R. Somasagara, Mahesh Hegde, Mayilaadumveettil Nishana, Satish Kumar Tadi, Mrinal Srivastava, Bibha Choudhary & Sathees C. Raghavan. (Scientific Report)
No comments:
Post a Comment