Wednesday, 24 July 2019

Herbal Ashwagandha Eradicates Stomach/Gastric Cancer in Vitro

By Kyle J. Norton

The stomach formed part of the digestive system that receives food from the esophagus before passing them to the small intestine is a muscular organ located on the left side of the upper abdomen.

The stomach is the first line of food digestive by secreting acid and enzymes.

Gastric/Stomach cancer is a medical and chronic condition caused by the cell growth irregularly and disorderly in the cells on the surface of the inner lining tissue before penetrating deeper into to other layers of the stomach to form a tumor,  due to the alternation of DNA.

Researchers do not know the exact causes of gastric cancer. However, researchers do know the increase in age, gender, ethnicity, geography, Infection with Helicobacter pylori (H pylori) and poor diet are some prevalent factors found in patients with the disease.

At the later stage, the large tumor size may suppress the nearby blood vessels and nerve cells, leading to internal bleeding and severe pain. Also, cancer cells may travel a distance away from the stomach to infect other healthy tissue and organs, leading to a secondary metastasis that develops in the liver (48%), peritoneum (32%), lung (15%), and bone (12%).

According to the American Cancer Society, in 2018, approximately 26,240 new cases of gastric cancer were diagnosed (16,520 in men and 9,720 in women), and gastric cancer caused the death of 10,800 people including 6,510 men and 4,290 women.

The 5 years survival rate of localized gastric cancer is 67%, compared to the advanced stage of only 31%.

Although there are many risk factors involved the onset of gastric cancer, epidemiologically, some researchers suggested the change of diet may prevent the onset of gastric cancer.

According to the World Cancer Research Fund International, by reducing the list below in your diet, gastric cancer may be preventable.

"Alcoholic drinks: Consumption of alcoholic drinks is probably a cause of stomach cancer. This is based on evidence for intakes greater than 45 grams per day (about 3 drinks a day).

Foods preserved by salting: Consumption of foods preserved by salting is probably a cause of stomach cancer.

Processed meat: Consumption of processed meat is probably a cause of non-cardia cancer.

Grilled (broiled) or barbecued (charbroiled) meat The evidence suggesting that consumption of grilled (broiled) and barbecued (charbroiled) meat increase the risk of stomach cancer is limited.

 Low fruit intake: The evidence suggesting that low intake of fruit increases the risk of stomach cancer is limited.

Citrus fruit: The evidence suggesting that consumption of citrus fruit decreases the risk of cardia cancer is limited".


Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent ingredient for the treatment of cancer, researchers examined the effects of Withaferin A (WA), derived from Withania somnifera on anti colon cancer activity.

On AGS cells. WA at a dose-dependent exerted a strong cytotoxic effect on cell cycle arrest at the G2/M phase.

Furthermore, WA also exhibited the expression of proteins associated with the promotion of AGS cancer cells apoptosis.

Moreover, treatment with WA also inhibited the metastatic ability of cancer cell line by decreasing in the migration and invasion potency.

Dr. Kim J. after taking into account of other co and confound wrote, "WA directly inhibits the proliferation and metastatic activity of gastric cancer cells, and suggest that WA may be developed as a drug for the treatment of gastric cancer".

In Helicobacter pylori infection-induced gastric cancer, WA also inhibited the production of pro-inflammatory cytokines IL-1β involved in tumor initiation and progression by blocking the activation of sensor component of the NLRP3 inflammasome associated with the innate immunity in the inflammatory response.

In other words, WA protects the integrity of the dendritic cells by inhibiting IL-1β production by H. pylori in the induction of gastric cancer.

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of gastric cancer, pending to the results from larger sample size and multicenter study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis by Kim G1,2, Kim TH3, Hwang EH1,2, Chang KT2, Hong JJ2, Park JH. (PubMed)
(2) Withaferin A Inhibits Helicobacter pylori-induced Production of IL-1β in Dendritic Cells by Regulating NF-κB and NLRP3 Inflammasome Activation by Kim JE1, Lee JY2, Kang MJ2, Jeong YJ1, Choi JA1, Oh SM1, Lee KB1, Park JH. (PubMed)
(2) Diet, nutrition, physical activity and stomach cancer by  the World Cancer Research Fund International

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