Turmeric Protects the Renal Cells Integrity Against Kidney Disease

By Kyle J. Norton

The kidneys are two bean-shaped organs located just below the rib cage, one on each side of your spine.

The kidneys formed a second detoxed organ in the body after liver not only plays an essential role in regulating electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin,... but also filters blood that passes into the tubules. In the Urinary system, kidneys reabsorbed some necessary substances back into the blood, while waste, such as urea and ammonium are deposited into pelvis then into the ureter to the bladder for secretion.

Kidney disease is a condition that reduces the function of the kidney acutely or gradually.

Kidney cancer is a medical condition caused by irregular cell growth that starts in the cells on the surface of the inner lining tissue of the kidney due to the alternation of DNA. At the advanced stage, kidney cancer can spread via the bloodstream, leading to the second tumor generally found in the lung.

According to the statistics, approximately  14 percent of the US population suffer some forms of chronic kidney disease (CKD), including 661,000 cases of kidney failure.

 Believe it or not, almost half of the individuals with CKD also have diabetes and/or self-reported cardiovascular disease (CVD).

Blood in urine, protein in the urine, kidney stones, kidney infection, kidney pain, hepatitis C and other forms of kidney diseases are signs of kidney disease that can lead CKD.

If you experience some of the aforementioned symptoms that do not heal in a short period of time, please check with your doctor to rule out the possibility.

CKD if untreated can lead to kidney failure, the end-stage renal disease (ESRD).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

With an aim to find a potent compound for the treament of chronic kidney disease (CKD), researchers examined the turmeric anti antioxidant, anti-inflammatory, and anti-apoptotic activities on kidney structure and function in rats induced CKD by adenine.

The study included rats induced KD-like renal damage by adenine with three doses of curcumin for 5 weeks.

According to the markers of kidney function and oxidative stress,, urine, renal homogenates on kidney tissue, researchers found that

* Curcumin significantly abates adenine-induced toxic effects such as reduced creatinine clearance.

* Elevated neutrophil gelatinase-associated lipocalin levels induced by adenine associated with kidney damage are also inhibited by the injection curcumin.

* Curcumin also enhanced the levels of antioxidant enzyme in the kidney tissue by raising the urinary N-acetyl-β-D-glucosaminidase activities.

In other words, the bioactive compound isolated from turmeric curcumin strongly reduced renal morphological damage and histopathological markers of inflammation, such as the inflammatory cytokines IL-1β, IL-6 and TNF-α, cystatin C and adiponectin, involved in the formation of fibrosis, and kidney cell apoptosis.

Elevated plasma sclerostin concentrations and oxidative stress in renal homogenates induced by adenine were also inhibited by the presence of curcumin.

Furthermore, in animal experiments, administration of two higher curcumin concentrations, alone or in combination with adenine, also showed similar efficacy in increasing expression of the antioxidative transcription factor (Nrf2) and the activity against oxidative stress in the kidney tissue.

Based on the results, researchers said, "curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2".

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of chronic kidney disease, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin and chronic kidney disease (CKD): major mode of action through stimulating endogenous intestinal alkaline phosphatase by Ghosh SS1, Gehr TW2, Ghosh S. (PubMed)
(2) Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease by Ali BH1, Al-Salam S2, Al Suleimani Y1, Al Kalbani J1, Al Bahlani S3, Ashique M1, Manoj P1, Al Dhahli B3, Al Abri N4, Naser HT2, Yasin J5, Nemmar A6, Al Za'abi M1, Hartmann C7, Schupp N. (PubMed)