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Saturday, 17 May 2014

Phytochemical Allyl isothiocyanate and liver cancers

Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Liver cancer is defined as a condition of irregular cell growth in the liver.

In SK-Hep1 human hepatoma cells, Allyl isothiocyanate (AITC) showed to exhibit its anti liver cancer effect through suppressing tumor cell migration and cell behaviors via MMP expression, which plays an important role in breaking down of different human cancers with poor disease prognosis(1).
The phytochemical together with its N-acetylcysteine conjugate also showed the reversal of transcriptase polymerase chain reaction in dose-dependent manner through inhibition of MMP-2/-9 messenger RNA levels which involves in cell proliferation (2). Unfortunately, some researchers suggested that Organosulfur compounds, may induced histone acetylation expression, the enzymes fundamental roles in developmental processes and their deregulation has been linked to the progression of diverse human disorders, such as cancers(4) and thereby favor cell differentiation(3).


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References

References
(1) Allyl isothiocyanate influences cell adhesion, migration and metalloproteinase gene expression in SK-Hep1 cells by Hwang ES1, Kim GH.(PubMed)
(2) Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells by Hwang ES1, Lee HJ.(PubMed)
(3) Induction of histone acetylation in rat liver and hepatoma by organosulfur compounds including diallyl disulfide by Lea MA1, Randolph VM.(PubMed)(1).
the phytochemical together with its N-acetylcysteine conjugate also showed the reversal of transcriptase polymerase chain reaction in dose-dependent manner also through inhibition of MMP-2/-9 messenger RNA levels(2). Unfortunately, some researchers suggested that Organosulfur compounds, may induced histone acetylation expression and thereby favor cell differentiation(3).
(4) Role of histone acetylation in the control of gene expression by Verdone L1, Caserta M, Di Mauro E.(PubMed)