Guaianolides matricarin and achillin, acetoxyachillin and leucodin (= desacetoxymatricarin), corresponding C-11 stereoisomers(a),(Z)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (cis-GMCA), chlorogenic acid, (E)-2-β-d-glucopyranosyloxy-4-methoxycinnamic acid (trans-GMCA), quercetagetin-7-O-β-d-glucopyranoside, luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, chamaemeloside, apigenin 7-O-(6″-O-acetyl-β-d-glucopyranoside), apigenin] and one polyacetylene (tonghaosu)(b).
Dermatitis or eczema, is defined as a condition of inflammation of skin including itchy, erythematous, vesicular, weeping, and crusting patches.
The use of chamomile oil in folk medicine for treatment of skin disorder may have found to be effect in modern medicine, according to Howon University, application of German chamomile oil to alleviating atopic dermatitis, such as reduced serum IgG1 level and significantly lower serum histamine level through influencing of Th2 cell activation(1).
Dr Dohil MA. in the study of herbal effects on in atopic dermatitis and other inflammatory skin disease, indicated that there may be a positive effect of herbal medicine, including chamomile through the present recent multicenter and international clinical studies that support their efficacy and safety profile for a variety of inflammatory skin conditions(2). and herbs containing anti inflammatory activity such as chamomile may be particularly well suited as alternatives to pharmacologic therapies in chronic conditions for which long-term use is required,(3), Dr. Wu J. said.
Although, German chamomile may be effective for treatment of skin disorder, but it was found to have allergic effect in some patients, in external use of chamomile tea or use of chamomile-containing topical herbal remedies, due to its chemical constituent herniarin(4).
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(1) Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.by Lee SH1, Heo Y, Kim YC.(PubMed)
(2) Natural ingredients in atopic dermatitis and other inflammatory skin disease.