Monday, 19 May 2014

Phytochemical Allyl isothiocyanate and Prostate Cancer

 Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color. Phytochemicals may be next potential sources of new medicine for treatment of diseases with little or no side effects.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Prostate cancer is defined as a condition in which the cells of prostate has become cancerous, causing abnormal cell growth which spread to the distant parts of the body. Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

In PC-3 human prostate cancer xenografts, ATIC found abundantly in cruciferous vegetables exhibited its anti prostate cancer effect inhibits through inducing apoptosis and reducing cell proliferative activity(1). The University of Pittsburgh School of Medicine study also supported the above but insisted ATIC inhibit prostate cancer through cell cycle arrest (G2/M)and induced apoptosis(2) and The State University of New Jersey, showed the inhibition through ERK and JNK signaling pathways(cellular processes in regulation of Proliferation, Differentiation, Survival and Apoptosis) involvement in the regulation of activator protein 1 and cell death(3).

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(1) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo by Srivastava SK1, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV.(PubMed)
(2) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis vy Xiao D1, Srivastava SK, Lew KL, Zeng Y, Hershberger P, Johnson CS, Trump DL, Singh SV.(PubMed)
(3) ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells by Xu C1, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN.(PubMed)