Sunday, 11 May 2014

Herbal Therapy - Calendula as Antioxidants

Calendula is also known as pot marigold, a annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe. It has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.

Beside major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil,carotenoids and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.

A randomized controlled clinical study, conducted by Babol University of Medical Sciences on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer, showed a effectiveness of Calendula officinalis flowers extract mouthwash on decreasing the intensity of radiotherapy- induced OM during the treatment, probably through its antioxidant capacity(1). In experimentally induced thermal burns in rats, the extract not only significantly lowered issue damage marker enzymes- alkaline phosphatase, alanine and aspartate transaminases in a dose dependant manner(2) but showed a protective role against CCl4 induced acute hepatotoxicity and cisplatin induced nephrotoxicity, possibly through mechanism of action of its antioxidant activity and reduction of oxygen radicals(3).

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(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA.(PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)