Friday, 30 May 2014

Phytochemical Isothiocyanates and heart diseases

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Beside cancer, heart disease kills more than 2,000 Americans everyday. Approximately 60 million Americans have heart disease.
There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat.
In human immunodeficiency virus (HIV) patients, showed to improve AIDS-related heart dysfunction through inhibition of apoptosis by decreasing iNOS and Bax expression through suppression of NF-κB.(1). In ischemic injury of hearts patients, showed to inhibit reactive oxygen species mediators in exerting a toxic effect during ischemia-reperfusion through mitochondrial K(ATP) channels and antioxidant pathway(2). On ischaemia-reperfusion-induced cardiac injury. steamed broccoli  showed a superior cardioprotective properties over cooked broccoli, probably through through the redox signalling of sulphoraphane(3). the phytochemical also found to trduce risk of vascular disease due to aging by inhibiting oxidative stress (4).

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(1) Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle. by Ho JN1, Yoon HG, Park CS, Kim S, Jun W, Choue R, Lee J.(PubMed)
(2) Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) Piao CS1, Gao S, Lee GH, Kim do S, Park BH, Chae SW, Chae HJ, Kim SH.(PubMed)
(3) Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. by Mukherjee S1, Lekli I, Ray D, Gangopadhyay H, Raychaudhuri U, Das DK.(PubMed)
(4) Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging by Chapple SJ1, Siow RC, Mann GE.(PubMed)