Saturday, 17 May 2014

Cayenne and Breast cancer

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8.

The chemical constituents of Cayenne include capsaicin,  capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.

The benefits
Capsaicin found in red peppers of the genus Capsicum has been effectively exerting its biological activities (anticarcinogenic, antimutagenic and chemopreventive) in many cancer cell lines. 
In breast cancer cell line MCF-7, treatment with capsaicin for 24 h resulted cells apoptosis in dose dependent manner through a caspase-independent pathway, which plays an important role in ensuring the effective removal of defective cells(5) MCF-7 cells. Other, in the study of the same showed that Capsaicin extract induced significant growth arrest and apoptosis in human breast and leukemia cancer cell lines in vitro with no significant effect on normal breast epithelial cells. These result suggested cayenne may be a potential agent in treating breast cancer.

The Side Effects
1. It may cause allergic reaction in young children
2. It may also cause hypertensive response if overdosed.
3. It may promote symptoms of acute anal fissure.
4. It may cause burning sensation to certain people in the first taste
5. Do not use cayenne pepper in young children
6. Etc.

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(1) "Severe pepper allergy in a young child" by Gimenez L, Zacharisen M(PubMed))
(2) Mechanisms underlying the hypertensive response induced by capsaicin" by Dutta A, Deshpande SB.(PubMed)
(3) Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures" by Gupta PJ.(PubMed)
(4) Tumor cell growth inhibition is correlated with levels of capsaicin present in hot peppers by Dou D, Ahmad A, Yang H, Sarkar FH.(PubMed)(5) Capsaicin-induced apoptosis in human breast cancer MCF-7 cells through caspase-independent pathway by Chou CC, Wu YC, Wang YF, Chou MJ, Kuo SJ, Chen DR.(PubMed)
(5) Caspase-independent pathways of programmed cell death: the unraveling of new targets of cancer therapy? by Constantinou C1, Papas KA, Constantinou AI.(PubMed)

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