Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Cardiac fibrosis is a uncommon condition of abnormal thickening of the heart valves caused by inappropriate proliferation of cardiac fibroblasts but commonly, it is the excess deposition of molecules outside a cell or cells with structural and biochemical support to the surrounding cells in the cardiac muscle, leading to cardiac dysfunction and eventually heart failure.
The study of rat cardiac fibroblasts caused by injected by angiotensinII (AngII) also revealed that green tea inhibited the abnormal increase in level of connective tissue growth factor CTGF by decreased expression of the nuclear translocation of NF-κB p65 subunit and degradation of IκB-α in induced promotion of fibroblast proliferation and extracellular matrix (ECM) accumulation, thereby exacerbating cardiac hypertrophy and subsequent failure were attributed to bioactive polyphenol EGCG expression in significantly reduced collagen synthesis, fibronectin (FN) expression and cell proliferation.
Interestingly, in the evaluated the effect of GABA tea, containing a high level of gamma-aminobutyric acid (GABA) in cardiac function with male Wistar rats injected with 55 mg/kg streptozotocin (STZ) to induce diabetes for 2 weeks and then orally given dosages of 4.55 and 45.5 mg/kg/day GABA tea extract for 6 weeks, researchers revealed that rats treated with injection of GABA tea not only induces fasting blood glucose levels returned to normal levels but also inhibits cardiac fibrosis in compared to untreated group.
Unfortunately, injection of bioactive polyphenols (-)-Epigallocatechin-3-gallate (EGCG) in high dose was found to induce the oppositely effect by increasing cardiac fibroids.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) GABA tea prevents cardiac fibrosis by attenuating TNF-alpha and Fas/FasL-mediated apoptosis in streptozotocin-induced diabetic rats by Cherng SH1, Huang CY2, Kuo WW3, Lai SE4, Tseng CY5, Lin YM6, Tsai FJ7, Wang HF8.(PubMed)
(2) High doses of (-)-epigallocatechin-3-gallate from green tea induces cardiac fibrosis in mice by Cai Y1, He SQ2, Hong HQ3, Cai YP4, Zhao L5, Zhang M2.(PubMed)
(3) EGCG inhibits CTGF expression via blocking NF-κB activation in cardiac fibroblast by Cai Y1, Yu SS, Chen TT, Gao S, Geng B, Yu Y, Ye JT, Liu PQ.(PubMed)