Friday, 26 January 2018

Herbal Therapy: Green Tea and Its Bioactive Polyphenol in Reduced Risk and Treatment of All Forms of Acne

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in prevention and treatment of acne, some scientists suggested.

Green tea, is a precious drink with numbers of health benefit known to almost everyone in Asia and Western world.

Acne is a condition of skin diseases characterized by the occurrence of inflamed or infected sebaceous glands in the skin.

In the examined the effects of EGCG, the bioactive major polyphenol of green tea on human SEB-1 sebocytes with function in secreted sebum in patients with acne, researchers found that EGCG exerted a significant antioxidant activity in reduced sebum secretion by modulating the AMPK -SREBP-1 signaling pathway through AMPK expression in stimulated EGCG effect in regulated the interaction of  phosphorylates sterol regulatory element binding proteins SREBP-1.

Application of green tea EGCG also demonstrated a strong effect in reduced sebum in induction of inflammation of sebaceous glands by suppressing the NF-κB in induced transcription of proinflammatory genes in cellular response to stress and pathogens and AP-1 pathway, a transcription factor with function in regulated gene expression of inflammation factors in response to a variety of stimuli, including bacterial and viral infections.

Furthermore, administration of EGCG also found to have a huge effect in targeting almost all the pathogenic features of acne through exhibited a significant cytotoxicity of SEB-1 sebocytes in induction of viability of P. acnes,

Dr. Yoon JY, the lead author at the Seoul National University Hospital, after taking into account of all findings said, " EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated".

Amazingly, the randomized, double-blind, placebo-controlled clinical trial conducted from May 2012 through October 2013.of a total of 64 of 80 women, from 25 to 45 years of age with moderate-to-severe acne randomly assigned to receive either 1500 mg of decaffeinated GTE or placebo (cellulose) daily for 4 weeks indicated that there were statistically significant differences in inflammatory lesion counts found on the nose, periorally and on the chin between the two groups but no significant differences of total lesion counts.

Within group, green tea application displayed significant reductions in inflammatory lesions distributed on the forehead and cheek with no difference in total lesion counts.

Moreover, green tea group also resulted in significant reduction of total cholesterol levels in compared to cellulose group.

However, due to limitation of the small sample and short time period, researchers postulated that more research is required to determine whether a decaffeinated GTE standardized for EGCG content will provide clinical benefits in women with post-adolescent acne.

Additionally, in selected 59 studies with eight met the inclusion criteria to evaluate the effect of tea polyphenols in reduced sebum production in the skin and for treatment of acne vulgaris by reviewing  the literature published on PubMed, researchers suggested that application of tea polyphenols topically may have a beneficial effect in reducing sebum secretion and in treatment of acne through inhibited lipid synthesis by the sebaceous glands.

Truly, according to the University of Miami, in the examine 12 patients with mild-to-moderate acne vulgaris received green tea application twice daily for a period of 6 weeks, topical injection of 2% green tea lotion was found to be effective in treatment with statistically significant in mean total lesion count (TLC) decreased from 24 measured at the baseline to 10 after 6 weeks treatment, a reduction of 58.33%.

The mean severity index (SI) from all patients also decreased from 2.05 before treatment to 1.25 after 6 weeks treatment, a decrease of 39.02%.

Dr. Elsaie ML, the lead scientists said, "Topical 2% green tea lotion is an effective, cost-effective treatment for mild-to-moderate acne vulgaris".

Taking altogether, green tea and its bioactive major polyphenol may be used safely in reduced risk, progression and treatment of all form of acne pending to a large sample size and multi centers clinical trial. Oral administration of green tea should be taken with exceptional care as some cases of acute liver toxicity were reported literaturally.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris by Saric S1, Notay M2, Sivamani RK(PubMed)
(2) Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial by Lu PH1, Hsu CH2.(PubMed)
(3) Epigallocatechin-3-gallate improves acne in humans by modulating intracellular molecular targets and inhibiting P. acnes by Yoon JY1, Kwon HH, Min SU, Thiboutot DM, Suh DH.(PubMed)
(4) The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris by Elsaie ML1, Abdelhamid MF, Elsaaiee LT, Emam HM.(PubMed)

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