Monday, 22 January 2018

Herbal Therapy: Green Tea in Reduced Risk of Gut Microbiota Imbalance in Induction of Obesity and Gastrointestinal Diseases

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in improved microbiota  imbalance in Induction of obesity and gastrointestinal diseases, some scientists suggested.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Gut microbiota are microorganisms that lived in the digestive tracts in humans and animals.

According to the evaluation of obesity induced of C57BL/6 J male mice by feeding a high fat (HF) diet for 8 weeks, followed by treatment with oral tea saponin (0.5%) mixed in HF diet for a further 6 weeks, injection of tea saponin (0.5%) mice demonstrated a impressive activity in ameliorated endotoxemia which cause by accumulation of endotoxins in the blood, an indication of over production of gram-negative rod-shaped bacteria, reduced numbers of pro-inflammatory macrophage accumulation in the colon in exhibited colon inflammation and gut microbiota alterations in reduced expression of good bacteria, such as Bifidobacteria, Lactobacillus,... and over expression of harmful bacteria Escherichia Coli and Enterobacter caused by HF diet.

Patients with digestive disorders have been found to associate to imbalance of gut microbiota and dysbiosis of the gut bacteria communities that can lead to many chronic issues and diseases, including irritable bowel syndrome (IBS), coeliac disease, inflammatory bowel disease, obesity, colon cancer, and autism......, 

In fact, balancing of gut microbiota plays an important role in the harvest, storage, and expenditure of energy obtained from the diet and dysfunction of the community is associated  various causes in induction of obesity and malnutrition.

According to the study, teasaponin also improved glucose tolerance and reduced body weight gain in HF diet-induced obese mice that may be an expression of green tea extract in limit unfavorable gut microbiota alterations in HF diet-induced obesity.

Additional analysis of orally administration of three types of tea infusions for 13 weeks in high-fat-diet induced obese C57BL/6J mice to examine their anti-obesity and gut microbiota modulatory effects.suggested that application of the tea infusion showed strong effect in the prevention of the development of obesity with no significant differences and expressed a substantially increased diversity and altered the structure of gut microbiota in tested mice.

According to the high-throughput MiSeq sequencing, multivariate statistical and linear discriminant assays, Dr. iu Z, the lead author at the Fuzhou University said, "tea infusion consumption substantially increased diversity and altered the structure of gut microbiota" and "(Some) key phylotypes (such as Alistipes, Rikenella, Lachnospiraceae, Akkermansia, Bacteroides,...) might have a close association with the obesity related indexes of the host".

Interestingly, in male Swiss albino mice were fed with HFD (58% fat kcal) induced alterations of gut microbiota for 12 weeks, green tea extract (GTE) and isomalto-oligosaccharide (IMOs), a naturally occurring plant-based dietary injection, significantly improved liver metabolome associated with lipid metabolism and prevented imbalance of gut microbiota in damage of the lining of the small intestine (leaky gut), through reduced expression of lipopolysaccharides(LPS) in the blood stream(an indication of serve inflammation) and pro-inflammatory cytokines (e.g. resistin, TNF-α, and IL-1β).

Dr. Singh DP, the lead scientist at the University Institute of Pharmaceutical Sciences (UIPS) after differentiating above illustration said, " Combination (of GTE and IMOs restores the balance of gut microbiota through), improved beneficial gut microbiota (Lactobacillus sp., Bifidobacteria, Akkermansia muciniphila, Roseburia spp.) abundances, restored Firmicutes/Bacteriodetes and improved Prevotella/Bacteroides proportions".

Taking altogether, green tea and its phytochemical constituents expressed strongly improved beneficial effects on multiple parameters in maintaining the favorable gut microbiota ratio in reduced risk of the onset of certain diseases, including obesity, celiac disease, inflammatory bowel disease.

Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline in diet-induced obese mice by Wang S1,2, Huang XF3,4, Zhang P1,5, Newell KA1, Wang H1, Zheng K5, Yu Y6,7.(PubMed)
(2) The modulatory effect of infusions of green tea, oolong tea, and black tea on gut microbiota in high-fat-induced obese mice by Liu Z1, Chen Z1, Guo H1, He D1, Zhao H1, Wang Z1, Zhang W1, Liao L1, Zhang C1, Ni L1.(PubMed)
(3) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice by Singh DP1, Singh J2, Boparai RK3, Zhu J4, Mantri S2, Khare P1, Khardori R5, Kondepudi KK6, Chopra K7, Bishnoi M8.(PubMed)

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