Tuesday, 9 January 2018

Food Therapy: Lentil (Plant) Lectin in Attenuated Risk and Treatment of Breast Cancer

Kyle J. Norton

Lentils (Legume) lectin may consist a therapeutic and chemo effect in reduced risk and treatment of breast cancer, some researchers suggested.

Lentil, a type of pulse and tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens the Fabaceae family, native to Middle East.

Breast cancer is a medical condition characterized by cell growth disorderly in the breast tissues. At the late stage, the cancerous cell can travel a distance way from the original site to infect other healthy tissues and organs.

Differentiation of lectin effect in risk of breast cancer are depending to several different mechanisms through various aspects.

Lectins from various sources are proteins or glycoproteins specifically and reversibly bind to different types glycoproteins, with anti tumor activity in inhibited altered glycosylation of cell surface glycoproteins in breast cancer subjects.

In breast cancer cell lines, application of lectin induced cytotoxicity against MCF- 7 cell line through induction of cancer cell apoptosis, observed by DNA ladder assay.

Additionally, lectin extract also exerted a significant effect in exhibited function of PARP cleavage in initiated breast cell death processes, in dose-depend manner.

Moreover, the anti proliferation and apoptosis of lectin also demonstrated the increase of P21 level in association to cell cycle arrest in MCF-7 cell line, through inhibited the activity of cyclin D, a member of the cyclin protein family involved in regulating cell cycle progression.

Additional study of H3, a lectin anti tumor effect in binding to tumor associated carbohydrates antigens and precipitated human breast cancer cell line MCF7 apoptosis indicated that H3 exhibited anti breast cancer in induction of a significant arrest in the G1 cell cycle phase, through increasing expression of caspase-9 (CASP 9), a cysteine-aspartic protease with function in implication of apoptosis through cytokine signalling.

Interestingly, injection of H3 not only impaired dramatically the adhesiveness of MCF7 cells, but also exhibited increase of organelle acidity in promotion of cancer cell death, through conversion of LC3-I, to its conjugate LC3-II, an indication of autophagy, observed by Western blot.

In depth study of the effect other plant lectin in risk of breast cancer, researchers also found that bauhinia forficata lectin (BfL) inhibited the viability of the MCF7 cell line through increased α5 subunit expression in exhibition of metastasis suppression, and induced cell death through activation of cell apoptotic Caspase-9, cysteine-aspartic protease.

Amazingly, the infection of bauhinia forficata lectin (BfL) also precipitated deoxyribonucleic acid (DNA) fragmentation, an indication of cell cycle arrest in 2 phase of cell division as well as decreasing expression of the proteins pRb and p21.in regulated cell cycle progression and survival.

Taken together, lectins from many sources, including lentils may be used as secondary and therapeutic therapy combination with standard treatment to ameliorate progression and  treatment of breast cancer.

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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Halilectin-3, a lectin from the marine sponge Haliclona caerulea, induces apoptosis and autophagy in human breast cancer MCF7 cells through caspase-9 pathway and LC3-II protein expression
do Nascimento-Neto LG1,2, Cabral MG2, Carneiro RF3, Silva Z4, Arruda FVS2,5, Nagano CS3, Fernandes AR4, Sampaio AH3, Teixeira EH#1,3, Videira PA#4.
(2) Bauhinia forficata lectin (BfL) induces cell death and inhibits integrin-mediated adhesion on MCF7 human breast cancer cells by Silva MC1, de Paula CA1, Ferreira JG1, Paredes-Gamero EJ2, Vaz AM3, Sampaio MU1, Correia MT4, Oliva ML5.(PubMed)
(3) A novel L-fucose-binding lectin from Fenneropenaeus indicus induced cytotoxicity in breast cancer cells by Chatterjee B1, Ghosh K1, Yadav N1, Kanade SR2.(PubMed)

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