Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Bone cancer is medical condition characterized by irregular cell growth in the issues of colon At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away drom the original site.
According to statistic, early stage of bone cancer diagnosis of 5-year survival rate are approximately 85%.
In the evaluation of the effect of solamargine, a steroidal glycoalkaloid against human osteosarcoma
U2OS cells, researchers at the Shandong University showed that application of solamargine exerted a substantially reduced cell viability and induced apoptosis in osteosarcoma U2OS cells through over expression of mRNA and protein expressions of p53 in regulated the cell cycle in involvement of tumor suppression and Bax in expression of a pro-apoptotic regulators involved in a wide variety of cellular activities and activated apoptosis and reduced expression of Bcl-2 with function against cell apoptosis.
Dr. Li X1, the lead scientist said, "(the results finding, indicated that) Solamargine activates the mitochondria-mediated apoptotic pathway in U2OS cells via both p53 transcription-dependent and -independent mechanisms".
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1.(PubMed)
(2) Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells by Li X1, Zhao Y, Wu WK, Liu S, Cui M, Lou H.(PubMed)