Herbal Therapy: Green Tea and Its Bioactive Polyphenols in Reduced Risk, Progression and Treatment of Oral Cancer

Kyle J. Norton 

Green tea may have a profound and sustainable effect in reduced risk and treatment of oral cancer, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory. Adding a slice of ginger will neutralize the risk.

Oral cancer is medical condition characterized by irregular cell growth in the issues of mouth area. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, 1 in 75 men and 1 in 150 women will be diagnosed with oral cancer during their lifetime

In the review of medical literature online, green tea extract green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) showed to reduced risk and treatment of oral cancers through some particular mechanisms.

In human oral squamous carcinoma cells (SCC-25, SCC-9), application of green tea catechin, (-)-epigallocatechin-3-gallate (EGCG) suppressed SIRT3 mRNA and protein expression in induction of  SCC-25 cells proliferation, through antioxidant effect in attenuated function of SIRT3 in contribution to cancer cell survival via mRNA transmitting by modulating oxidative stress..

Some reserachers also insisted that SIRT 3 may be considered as a bio-maker for targeting stage and grade of cancer progression.

Further analysis, suggested that green tea bioactive EGCG also up regulated the nuclear localization of the estrogen-related receptor α (ERRα) in inhibited oral cell carcinoma tumors by regulating SIRT3 in expression of cancer cellular metabolism.

Interestingly, EGCG application also displayed a significant effect in modulated the mRNA expressions of SIRT3-associated to cancer cell in induction of cell proliferation through inhibiting the production of reactive oxidative species in precipitated chain reactive in initiation of cancer cell division.

More importantly, in ROS perspective, oral administration of green tea EGCG by targeting the protein SIRT3 in exhibited antioxidant effect in protect healthy cells without affecting formation of ROS to facilitate oral cancer cell apoptosis through cytotoxicity.

Dr. Tao L, after taking into account of other cofounders, said, "SIRT3 represents a novel potential target through which EGCG exerts differential prooxidant effects in cancer and normal cells".

Further observation of the efficacy of green tea extract EGCG, also indicated that EGCG treatment increased the production of mitochondrial H2O2 in SCC-25 cells within 6 hours before inducing cancer cells apoptosis.

In antioxidant activity. green extract EGCG induced differential expression of genes related to antioxidant defense in oral cancer cell and gingival fibroblasts, which are critical in sustaining inflammation in periodontal disease through ameliorated expression of metallothionein 3 in induction of degeneration of cells and superoxide dismutase 2/3, and thioredoxin reductase 2 in facilitate oxidative stress to induce oncogenesis without increased cell proliferation of human gingival fibroblast -1 (HGF-1).

Additional examination indicated that the application also exhibited anti oral cancer apoptosis by increased expression of mitochondrial ROS and mitochondrial dysfunction in facilitated intoxicate effect without causing harm to the gingival fibroblasts through antioxidant selective activities.

Green tea with promising chemo properties due to their decreased dose and limited toxicity profiles, Dr. Ramshankar V1, the lead author said, "It is worthwhile to include green tea extract in an oral screening program for evaluating the pre-malignant lesions comparing the results between the treated and untreated group. Given the wide acceptance of green tea, its benefits may help in effective chemo-prevention oral cancer".

Taken together, green tea with abundant bioactive polyphennols may be considered as a function for prevention and used as adjunct therapy in combination with standard treatment of oral cancer. Intake of green tea extract as supplement are not recommended as toxicity has been reported in numbers of case.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Differential prooxidative effects of the green tea polyphenol, (-)-epigallocatechin-3-gallate, in normal and oral cancer cells are related to differences in sirtuin 3 signaling by Tao L1, Park JY, Lambert JD.(PubMed)
(2) The role of the mitochondrial oxidative stress in the cytotoxic effects of the green tea catechin, (-)-epigallocatechin-3-gallate, in oral cells.by Tao L1, Forester SC, Lambert JD.(PubMed)
(3) Chemoprevention of oral cancer: Green tea experience by Ramshankar V1, Krishnamurthy A2.(PubMed)