Wednesday, 31 January 2018

Herbal Therapy: Green Tea and Its Bioactive (-)-epigallocatechin-3-gallate (EGCG) in Attenuated Risk and Treatment of Nasal Polyps

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and treatment of stomach polyps, some scientists suggested.

Green tea, is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Nasal polyps are small clump of cells that form on the inside lining of tissue of nasal passages or sinuses. In most cases, the development do not exhibit any symptom to the patients.

In the evaluation of The anti oxidative effects of major catechin from green tea is (-)-epigallocatechin-3-gallate (EGCG) on nasal polyps, chronic inflammatory conditions characterized by myofibroblast differentiation and extracelluar matrix accumulation, researchers at the Korea University College of Medicine found that application of the bioactive compound at dose of concentrations of 10-20 µg/mL demonstrated a strong activity in inhibition of the expressions of α-smooth muscle actin (αSMA) used to identify pathologic fibroblasts such as polyps and plays a role in fibroblast contractility and collagen type I mRNA in contribution to over expression of collagen biosynthesis.through reduced α-SMA and collagen protein levels.

At the same concentration, green tea is (-)-epigallocatechin-3-gallate (EGCG) inhibited expression of TGF-β1 in exhibited nasal polyp cells profileration through cytotoxitic activity caused by reactive oxygen species (ROS) in initiated free radical chain reaction and production.

Dr. Kang JS,  the lead author said," the possibility that EGCG may be effective at inhibiting the development of nasal polyps through an anti-oxidant effect".

Additionally, the examine of the inhibitory effects of epigallocatechin-3-gallate (EGCG) on the synthesis of hypoxia-induced vascular endothelial growth factor (VEGF) in nasal polyp fibroblasts (NPFs)also agreed that application of green tea activated antioxidant expression in inhibited nasal polyp fibroblasts through suppressed production of VEGF via the level of hypoxia-inducible factor (HIF-1)α in respond to decreases in available oxygen in the cellular environment induced by cobalt chloride.

Vascular endothelial growth factor (VEGF) is a protein with function in promoted production of new blood vessel to provide nutrient and oxygen to nasal polyp fibroblasts to facilitate abnormal cell growth activated by hypoxia-inducible factor (HIF-1)α.

Further differentiation also found that combined administration of Foligomycin (a specific HIF-1 alpha inhibitor) and EGCG expressed a more profound inhibition of VEGF synthesis in compared to oligomycin or EGCG treatment alone. 

After taking into account of other con founders Dr. Lin SK, the lead author at the National Taiwan University Hospital said, "Nasal polyp fibroblasts contribute to the pathogenesis of nasal polyps by producing VEGF to promote angiogenesis under hypoxic conditions. Epigallocatechin-3-gallate substantially diminishes HIF-1 alpha and VEGF synthesis in NPFs".

In transforming growth factor beta 1 or TGF-β1 a secreted protein that performs many cellular functions, stimulated nasal polyp fibroblasts (NPFs) proliferation treated with or without EGCG, showed that application of green expressed an impressive effect in inhibited TGF-β1 activities in activation of α-smooth muscle actin (α-SMA) in initiated fibroblast contractility and migration, NADPH oxidase-4 (Nox-4) in stimulated over production of reactive oxygen species, intracellular superoxide and type I collagen production in developed nasal polyp-derived fibroblasts.

The findings suggested that green tea EGCG may be an effective in inhibited development and growth of nasal polyps through its antioxidant activities.

Taking altogether, green tea with major bioactive (-)-epigallocatechin-3-gallate (EGCG) may be considered as function food in reduced risk and treatment of polyps without inducing adverse effects. However, intake of green tea extract should be taken with special as acute liver toxicity has been reported in numbers of case.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Epigallocatechin-3-gallate inhibits collagen production of nasal polyp-derived fibroblasts by Kang JS1, Park IH, Cho JS, Hong SM, Kim TH, Lee SH, Lee HM.(PubMed)
(2) Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis by Lin SK1, Shun CT, Kok SH, Wang CC, Hsiao TY, Liu CM.(PubMed)
(3) Green Tea Extract, (-)-epigallocatechin-3-gallate, Inhibits TGF-β1-stimulated Collagen Expression in Nasal Polyp Fibroblasts by H. Park, J. Cho, J. Kang, I. Park, H. Lee(The Journal of Allergy and Clinical immunology)

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