Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Prostate cancer is medical condition characterized by irregular cell growth in the issues of prostate. At the later stage, the cancerous cell may invade other healthy tissues and organs a distance away drom the original site.
According to statistic, approximately 11.6 percent of men will be diagnosed with prostate cancer at some point during their lifetime.
In deed, in the human prostate cancer cell PC-3. administration of non toxic dose of α-solanine initiated cancer suppression and reduced the viability of the human cancer cell through significantly elevated epithelial marker E-cadherin gene expression in target mutated cell in induction of cell profileration and invasion and decreased mesenchymal marker vimentin expression in initiated cell metastasis.
Moreover, α-solanine reduced levels of microRNA-21 (miR-21) in expression of cancer progression. Higher levels of miR-21 are correlated to more advanced malignancies and elevated tumor suppressor miR-138 expression in induced prostate cancer cells apoptosis through cell cycle arrest at G1/S transition.
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Impact In Rice, Pasta, And Potatoes In Half
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1.(PubMed)
(2) α-Solanine inhibits invasion of human prostate cancer cell by suppressing epithelial-mesenchymal transition and MMPs expression by Shen KH1, Liao AC2, Hung JH3, Lee WJ4, Hu KC5, Lin PT6, Liao RF7, Chen PS8.(PubMed)