Friday, 12 January 2018

Herbal Therapy: A Compilation of HOW Green Tea and Its Bioactive Epigallocatechin gallate EGCG in Reduced Risk and Treatment of Cardiovascular Diseases

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea containing bioactive polyphenols may have a strong implication in reduced risk and treatment of cardiovascular disease, some scientists postulated.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Cardiovascular disease are chronic medical condition characterized of narrowed or blocked blood vessels that can lead to a heart attack including chest pain (angina) or stroke.

According to statistic, heart disease is the second leading cause of death, claiming more than 48,000 lives every Canada.

In the differentiation of green tea bioactive polyphenols epigallocatechin gallate or EGCG in risk of cardiovascular disease researchers at the joint study lead by the Colorado State University found that application of EGCG activated the expression of the nuclear erythroid-2 like factor-2 (Nrf2) transcription factor in stimulated transcription of antioxidative genes in protection of cell against oxidative stress in induction of CVD.

In compared to statins, the conventional medicine may be effective in reduced heart attacks and strokes in people at moderate and high risk but it can also cause cancers and multi-drug resistance cancer, EGCG ameliorated risk of CVD without giving rise to adverse effects.

Further analysis of EGCG efficacy in risk of cardiovascular disease and metabolic syndrome by searching literature published online of major scientific databases, from 1995 to 2017, scientists found that EGCG exhibits a wide range of therapeutic properties including associated with the inhibition of LDL cholesterol in reduced risk of plague accumulated in the arterial wall in elevated risk of atherosclerosis, attenuated angiotensin II (AngII) through inhibiting transcription factor NF-κB in induced abnormal enlargement, or thickening of the heart muscle, and reduced risk of highly oxidative enzyme myeloperoxidase(MPO) activity in promoted myocardial infarction, as level of myeloperoxidase(MPO) is considered as a biomaker used in assessment of risk of heart attack.

Additionally, EGCG also exerted significant and profound effects in ameliorated risk of diabetes through lowering plasma glucoses and gycated haemoglobin level, inhibited pro inflammatory factors in elevated inflammation in the early phase of acute infection and chronic infection as well as blocking expression of ROS in stimulated free radical chain reaction through its antioxidant activity.

Dr. Eng QY, after taking into account of other con founders, siad, "EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases".

Moreover, in a total of 9 studies including 259,267 individuals satisfied the criteria and guideline included in the examining published literature in evaluated the association between green tea consumption, CVD, and ischemic related diseases. up to October 2014, researchers indicated that for non green tea drinker, risk of CVD was 1.19,  intracerebral hemorrhage was 1.24 and cerebral infarction was 1.15 in compared to people who drank <1 cup green tea per day.

Not surprisingly, people who drank 1-3 cups of green tea per day had a reduced risk of myocardial infarction 0.81, and stroke 0.64 in compared compared to those who drank <1 cup/day and who drank ≥4 cups/day had a reduced risk of myocardial infarction of 0.68 in compared to those who drank <1 cup/day.

And for people who consumed ≥10 cups/day of green tea were also shown to have lower LDL in compared to group who drank <3 cups/day.

Dr. Pang J, the lead author at the final stage of the experiment said, "(The) meta-analysis provides evidence that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular and ischemic related diseases".
The results finding of all studies confirmed that consumption of green tea is associated with favorable outcomes with respect to risk of cardiovascular disease as well as expression of various serum markers in compilation of how green tea initiated protective activity against CVD.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(*) Molecular understanding of Epigallocatechin gallate (EGCG) in cardiovascular and metabolic diseases by Eng QY1, Thanikachalam PV1, Ramamurthy S2.(PubMed)
(*) The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases.
Smith RE1, Tran K2, Smith CC3, McDonald M4, Shejwalkar P5, Hara K6.(PubMed)
(1) Green tea consumption and risk of cardiovascular and ischemic related diseases: A meta-analysis by Pang J1, Zhang Z2, Zheng TZ3, Bassig BA4, Mao C5, Liu X5, Zhu Y4, Shi K6, Ge J7, Yang YJ8, Dejia-Huang5, Bai M9, Peng Y9.(PubMed)

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