Wednesday 18 December 2019

Turmeric Modulates the macrophage Against the Risk of Atherosclerosis

By Kyle J. Norton

Atherosclerosis is a medical condition caused by plaques accumulated on the wall of the arteries, leading to narrowing the arteries in transporting oxygenated blood to the heart and other parts of the body.

Depending on the blood obstruction, atherosclerosis can induce different types of heart disease and stroke.

Plaque is the make of cholesterols, calcium, and other toxic substances, including cadmium.

According to the statistics provided by Atherosclerosis Open Acess, 32% of deaths account for atherosclerosis. 13.8% prevalence is among adults of 20 years and above. In 2010, coronary heart disease mortality rate was about 60%.

Risk factors of atherosclerosis include high blood pressure and cholesterol, diabetes, being overweight or obese, an unhealthy diet, a family history of heart disease and physical inactivity, particularly smoking.

Some researchers suggested that since cholesterol makes up a big part in the plaque, an unhealthy diet with a high saturated trans fat, red meat and processed meat may be the major cause of atherosclerosis.

Heart disease is a class of medical condition that affects your heart, including blood vessel diseases, such as coronary artery disease, heart rhythm problems such as arrhythmias, and congenital heart defects,

There are many causes of heart disease. Anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease. Here are some early indication of heart disease symptoms:

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as an anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to discover a natural ingredient for the prevention and treatment of heart diseases, researchers examined the effects of curcumin, a bioactive compound isolated from turmeric on atherosclerosis.

In vitro and in vivo, the administration of curcumin exerted lipid-lowering effects and modulated the function of different macrophage subsets in various macrophage-involved diseases, including atherosclerosis.

Curcumin attenuated the atherosclerotic plaques induced by microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes.

Moreover, curcumin regulated two main phenotypes called proinflammatory M1 and anti-inflammatory M2 macrophages against unstable plaques and senescent erythrocytes against the onset of plagues accumulation.

Based on the findings, researchers said, "The current review aimed to present role of macrophage subtypes in atherosclerosis development and progression and to understand the effect of curcumin on macrophage polarization and foam cell formation in the atherosclerosis lesion".


Taken altogether, turmeric processed a high amount of bioactive compound furanodiene may be considered supplements for the prevention of tumor metastasis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy by Momtazi-Borojeni AA1,2, Abdollahi E3,4, Nikfar B5, Chaichian S6,7, Ekhlasi-Hundrieser M. (PubMed)

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