Herbal Coltfoots (Tussilago farfara) in the Prevention of Liver Cancer

By Kyle J. Norton

Cancer is a class of chronic and medical conditions caused by the alternation of cell DNA.

The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.

Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to overexpression of overweight and obese of the population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.

According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.

In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.

On finding a natural ingredient for the protection of the liver functioning, researchers examined the effect of herbal on liver cancer, particularly in the induction of apoptosis through activation of the TRAIL pathway.

Coltsfoot(Tussilago farfara) is a perennial herbaceous plant, genus Tussilago, belonging to the family Asteraceae, native to Europe and Asia. The herb has been used over thousands of years to treat asthma, various coughs, bronchial congestion, respiratory disorders, headaches and obstruction in the nasal passage, etc.

Where TRAIL is a cytokine that is produced and secreted by most normal tissue cells, with a function to cause cell death.

According to the results of the analysis, the administration of Tussilago farfara L. (TF) exerted the effects of novel Indazole‐based MKK7–TIPRL inhibitor against liver cancer as TRAIL sensitizers.

Furthermore, co-treatment of human liver cells (Huh7 cells) with TF and TRAILdemonstrated a strong activity in the induction of apoptosis via inhibition of the MKK7-TIPRL interaction, a signal transduction pathway associated with cell death.

Based on the experimental results, researchers said, "TF as a novel TRAIL sensitizer, unveiling a potentially novel therapeutic strategy in cancer therapy".

Taken altogether, coltsfoot may be considered a remedy for the prevention and treatment of liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7‑TIPRL in human hepatocellular carcinoma cells by Lee HJ1, Cho HS1, Jun SY1, Lee JJ1, Yoon JY1, Lee JH1, Song HH2, Choi SH3, Kim SY3, Saloura V4, Park CG5, Kim NS. (PubMed)