Monday, 16 December 2019

Cranberry Normalizes the Circulating C-Reactive Protein Against the Risk of CVD

By Kyle J. Norton

C-reactive protein (CRP) is a protein made by the liver. The CRP levels used in the blood test to the diagnosis of inflammation in the body, particularly in patients with an infectious disease.

Furthermore, in some cases, levels of CRP are also used to monitor the severity of disease in chronic conditions.

According to the article of Healthline in examing the levels of CRP in Rheumatoid arthritis (RA) patients, "  Normal CRP levels are below 3.0 mg/L., and  "A high-sensitivity CRP test can detect levels below 10.0 mg/L. This kind of test is performed primarily to determine risk for cardiovascular disease".

Infection can be acute or chronic. In the acute phase of infection, after receiving the messages from the central nervous system related to the danger of microbial infection, the immune macrophages in the first line of defense stimulate the production of blood palette to the cover the wound and pro-inflammatory cytokines to the site of the infection to kill off pathogens which try to invade the body.

In most cases in a healthy individual, the immune system can easily eradicate all foreign invaders and the wound is recovered within days and weeks.

Symptoms of the acute infection include gastrointestinal discomforts, such as congestion vomiting or nausea, and diarrhea, short term joint or muscle pain, fever, headache, skin rash and cough, Some patients with acute infection also experience symptoms of swollen lymph nodes, an indication of the body in fighting infection.

In chronic infection, the symptoms are most vague or no specific symptoms, including bronchitis and asthma, persistent low-grade chronic joint and muscle pain, or swelling and the alternations between diarrhea and constipation, bloating, or heartburn, In other words, the symptoms are totally depended on the location of the low-grade inflammation.

Most cases of infection except those of viral infection are treated by topical antibiotic cream and/or oral antibiotics.

Conventionally, patients with elevated levels of CRP are associated with an increased risk of cardiovascular diseases (CVD).

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of diseases associated with inflammation, researchers investigated the potential of low-calorie cranberry juice (LCCJ) on lowering the cardiometabolic risk.

A double-blind, placebo-controlled, parallel-arm study conducted with controlled diets, including 30 women and 26 men (mean baseline characteristics: 50 y; weight, 79 kg; body mass index, 28 kg/m(2)) completed an 8-wk intervention with LCCJ or a flavor/color/energy-matched placebo beverage.

Twice daily, volunteers consumed 240 mL of LCCJ or the placebo beverage, containing 173 or 62 mg of phenolic compounds and 6.5 or 7.5 g of total sugar per 240-mL serving, respectively.

According to the results of the study, serum C-reactive protein (CRP) was, lower for individuals consuming LCCJ than individuals consuming the placebo beverage. 

More precisely, LCCJ expressed the transformed values of 0.522 ± 0.115 ln(mg/L) comapred to those of placebo of.0.997 ± 0.120 ln(mg/L).

Moreover, other parameters such as circulating TGs, insulin resistance, and diastolic BP
associated with the risk of cardiovascular diseases (CVD) were all reduced by the application of LCCJ.

Taken altogether, cranberry may be considered a remedy to lower CRP for reducing the risk of CVD, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults by Novotny JA1, Baer DJ2, Khoo C3, Gebauer SK2, Charron CS. (PubMed)
(2) Rheumatoid Arthritis: What CRP Levels Say About You by Healthline

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