Saturday, 28 December 2019

Phytochemical Tocopherols Kill Acute Myeloid Leukemia Cells in Vitro

By Kyle J. Norton

Leukemia is a condition characterized by an abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.

Bone marrow is soft tissue inside the hollow center of the major bone. including spine, pelvis, underarm, leg. etc.

Acute leukemia is a condition caused by a rapid increase in the numbers of extreme immature white blood cells that appear in the bloodstream in the other parts of the body, including tissue and organs.

 Acute leukemia can also be classified into
* Acute lymphoblastic leukemia (ALL)
Acute lymphocytic leukemia (ALL) is a type of cancer with the abnormal growth of extreme immature lymphocytes overproduced by the bone marrow and/or lymphatic system. The condition has a tendency to multiply quickly, leading to the death of normal white blood cells in the bone marrow and/or lymphatic system.

In ALL, lymphocytes appear immature in the bloodstream. Acute lymphoblastic leukemia (ALL) is the most common children forms of leukemia with about 80% of all cases.

* Acute myeloid leukemia (AML)
Acute myelogenous leukemia (AML) is a cancer of myelogenous lining caused by the rapid growth of abnormal granulocytes accumulated in the bone marrow, interfering with the normal blood cells. In AML, granulocytes appear immature in the bloodstream.

According to the statistics, in 2019, approximately 21,450 people of all ages including 11,650 men and boys and 9,800 women and girls) in the United States will be diagnosed with AML.

AML is the second most common type of leukemia diagnosed in adults and children, but most cases occur in adults. AML makes up 32% of all adult leukemia cases.

The 5-year survival rate for people 20 and older with AML is approximately 24%. For people younger than 20, the survival rate is 67%.

Tocopherols are phytochemicals of which many have vitamin E activity, belonging to the group of Lipids, found abundantly in butter, egg yolk, milk fat, some vegetable, and seed or nut oils, etc.

On finding a potential phytochemical for the treatment of leukemia, researchers examined the effect of δ-tocopherol in acute myeloid leukemia.

Compared to other leukemia cell lines, δ-T as low as 20 µM showed a strong activity on AML cell line KG-1.

The δ-T inhibition of AML cell line KG-1 was observed in a set of primary cells collected from patients newly diagnosed with AML.

Furthermore, δ-T also induced apoptosis and cell cycle arrest against KG-1 cells.

The results of δ-T anti-AML activity were attributed to the inhibition of protein cyclin-d1 associated with the G1 phase of the cell cycle arrest and a set of homeobox proteins associated with cancer cell growth and apoptosis.

Taken altogether, tocopherols may be considered a supplement for the prevention and treatment of acute myeloid leukemia pending to the confirmation of the larger sample size and multicenter human study.

Intake of tocopherols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Reduction in Cell Viability and in Homeobox Protein Levels Following in Vitro Exposure to δ-tocopherol in Acute Myeloid Leukemia by Collins J1, Safah H2, Lobelle-Rich P2, Whaley S3, Campbell S3, Saba NS. (PubMed)

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