Saturday, 14 December 2019

Healthy Food Common Fig or Fig (Ficus carica), the Anti Lipid Peroxidation Forming Functional Food

By Kyle J. Norton

Lipids are fat-like substances in your blood and body tissues that can not dissolve in water.

Lipid peroxidation induced oxidative degradation of lipids is a process caused by free radicals oxidation that leads to damage to the lipids in cell membranes.

More precisely, free radicals cause lipid peroxidation by oxidizing the free and ester forms of unsaturated fatty acids and cholesterol through three distinct mechanisms, including free radical-mediated chain reaction, enzyme-mediated oxidation, and nonradical, non-enzymatic oxidation.  All of these chemical reactions cannot be stopped until the electrons on the outermost ring of free radicals are paired or inhibited by antioxidants.

Free radicals are highly reactive molecules. Internally, they are produced by our body cell metabolism. Externally, free radical can enter our body from the environment sources, such as the air we breathe, the food we eat and the water we drink.

Free radicals have been found epidemiologically to damage the lipid, and protein and induce the alternation of healthy cell DNA.

Free radical scavengers are antioxidants that process the function to prevent the free radicals from being formed or remove them before they can damage vital components of the cell.

Antioxidants are stable atoms that play a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.

On finding a potential whole food for the treatment of lipid peroxidation, researchers examined the antioxidant properties of a major anthocyanin in fresh fig fruits, cyanidin-3-rhamnoglucoside (C3R) in vitro on cultured NIH-3T3 fibroblast cells.

Fig is a species of F. carica, belongings to the family Moraceae. thee veggie is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches

According to the tested differentiation, C3R inhibited lipid peroxidation from producing peroxy radicals (ROO(*)) and MDA by de-activating the expression of oxidative stress in a dose-dependent manner.

Furthermore, C3R showed a strong chelating activity against the forming of the anti-lipid peroxidation toward the Fe(2+) ion.

Most importantly, C3R exerted anti-apoptotic processes that were initiated by the oxidation of lysosome membranes in fibroblast cells.

In other words, C3R inhibited the initiation of lipid peroxidation of the tested cells by enhancing the antioxidant activity.

Based on the results, researchers wrote, "The high antioxidant potential, with several modes of action of purified C3R, may contribute to health benefits gained by the consumption of fresh fig fruits.".
Taken altogether, common fig or fig processed abundantly anthocyanin may be considered a remedy for the prevention of lipid peroxidation, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protection of fibroblasts (NIH-3T3) against oxidative damage by cyanidin-3-rhamnoglucoside isolated from fig fruits (Ficus carica L.) by Solomon A1, Golubowicz S, Yablowicz Z, Bergman M, Grossman S, Altman A, Kerem Z, Flaishman MA. (PubMed)

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