Tuesday, 24 December 2019

Healthy Food Cabbage, in Reducing the Risk of Cervical Cancer Developing

By Kyle J. Norton

Cervix formed part of the reproductive organ, is the lower part of the uterus that opens at the top of the vagina.

The cervix acts as a transition area (squamous columnar epithelium) for vaginal lining (squamous epithelium) to the uterus (columnar epithelium) to host the development of the fetus.

Cancer is the class of diseases associated with cell growth disorderly and uncontrollably due to the alternation of DNA.

Cervical cancer is a malignant neoplasm of the cervix uteri or cervical area caused by abnormal cells growth with alternation of cells DNA.

Researchers do not know what causes cervical cancer. Most cases of cervical cancer start in the cell on the surface of the inner lining tissue of the cervix. At this stage, most women with cervical cancer do not experience any symptoms.

At the advanced stage, invasive cancer can induce symptoms of abnormal bleeding, pain during sexual intercourse, increased vaginal discharge. If the tumor has suppressed the nearby nerve cells, cervical cancer can also cause localized severe pain.

According to the American Cancer Society's, in 2014, 12,360 new cases of invasive cervical cancer will be diagnosed with the death of 4,020 patients.

Epidemiological also suggested that HPV infection, sexual activity, smoking, giving birth many times. Infection with the human immunodeficiency virus (HIV, history of sexually transmitted infections (STIs) and long-term use of oral contraceptives are some prevalent risk factors of cervical cancer.

The risk of cervical cancer is also higher in Hispanic women followed by African-Americans, Asians and Pacific Islanders, and whites.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem that is crowded with a mass of green leaves, but in some varieties, it may be red or purplish.

With an aim to find a natural food that reduces the risk of malignant tumors, researchers investigated the activity of Indole-3-Carbinol (I3C), a phytochemical (derived from cabbage, and other cruciferous vegetables) on the reduction of cervical intraepithelial neoplasia (CIN) and its progression to cervical cancer.

According to the tested assays,
* In vitro, I3C inhibited the diminished PTEN expression during the progression from low-grade to high-grade cervical dysplasia in humans, 

In other words, the gene associated with tumor-suppressing activity not only was significantly inhibited before the onset of cervical cancer in patients with high-grade cervical dysplasia but also play a critical role in the initiation and progression of cervical intraepithelial neoplasia (CIN).

* In vivo, K14HPV16 transgenic mice model induced cervical cancer exerted overexpression of hormone estrogen.

* Dietary I3C in the tested models increased PTEN expression in the cervical epithelium of the transgenic mouse, to reduce the risk of development of cervical cancer.

Taken altogether, cabbage processed abundantly antioxidant I3C, may be considered a functional remedy for the prevention of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Indole-3-carbinol prevents PTEN loss in cervical cancer in vivo by Qi M1, Anderson AE, Chen DZ, Sun S, Auborn KJ. (PubMed)

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