Wednesday, 25 December 2019

Herbal Ashwagandha Process Anti-Parkinson's disease Activity

By Kyle J. Norton

Dementia is a medical and neurodegenerative disease characterized by the loss of mental ability, that is severe enough to interfere with people's every life.

Alzheimer's disease and Parkinson's disease (PD) are the most common types of dementia in aging people.

Dementia accounts for 5-8% of all people over the age of 65, and this number doubles every five years.

Parkinson's disease (PD) is a type of dementia that affects the nerve cells associated with the production of dopamine in the brain, leading to muscle rigidity, tremors, and changes in speech and gait.

In other words, Parkinson's disease is a progressive neurological disorder that affects neurons in transmitting messages in controlling the movement.

In the very early stage of PD, patients may not experience any symptoms. However, Parkinson's disease symptoms gradually worsen as the condition progresses.

As of today, researchers do not know why the neurons in the brain in some people are susceptible to gradually break down or die while others do not even they have similar health conditions and from the same family.

 Epidemiologically aging, gender, long-term exposure to certain toxic chemicals and genetic deposition are some of the prevalent factors involved in the increased risk of the disease.

Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.

The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.

On finding a potent compound for the prevention and treatment of neurological disorders, researchers examined the effects of Centella asiatica and Withania somnifera root extract consumption on Parkinson's disease in an animal model.

On 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson-like symptoms Balb/c mice, both ethanol extracts significant reduced the tested mice oxidative stress profile.

However, , the combination performed worse than either of the two individual constituents.

In other words, Withania somnifera and Centella asiatica treated individually showed a strong effect in reducing symptoms of Parkinson's disease comapred to the extract combination.

Based on the results, researchers said, " This effect of mixtures highlights the need for testing mixtures in supplements market using ethnomedicine. The necessity of comparing multiple groups in this study to get the most information from the experiments motivated us to design a ladder-like visualization to show comparison with different groups that we call complete comparison display (CCD)".

Taken altogether, Ashwagandha may be considered a functional herb for the prevention and treatment of Parkinson's disease symptoms, pending to the result of larger sample size and multicenter study

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Complete Comparison Display (CCD) evaluation of ethanol extracts of Centella asiatica and Withania somnifera shows that they can non-synergistically ameliorate biochemical and behavioural damages in MPTP induced Parkinson'smodel of mice by Bhatnagar M1, Goel I2, Roy T3, Shukla SD1,4, Khurana S. (PubMed)

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