Friday, 20 December 2019

Cramp Bark (Viburnum opulus) Exerts Cytoprotective Effects Against Colorectal Cancer in Vitro

By Kyle J. Norton

Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.

Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.

At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.

According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.

In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.

The cancer cytotoxicity is an activity to cause the destruction of cancer cells by causing cancer cell apoptosis

Cytotoxic activity is a process to induce toxic to cells.

Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.

On finding a potential herbal medicine for the prevention and treatment of cancer, researchers examined the effects of Cramp Bark(Viburnum opulus) extract cytoprotective activity on Caco-2 cell, the continuous line of heterogeneous human epithelial colorectal adenocarcinoma cells.

According to the tested analysis, the extract showed a strong anti-tumor property in modulating the cellular membrane dynamic in the progression of the cancer cells.

Furthermore, the application exerted a strong chemo-preventive activity against oxidative stress-induced chemically by tert-butyl hydroperoxide (t-BOOH).

Moreover, the antioxidants activity of the extract also inhibits DNA damage by initiating the  DNA self-repair after cell exposition to reactive oxygen species, methylnitronitrosoguanidine (MNNG) and H2O2.

Taken altogether, cramp bark(Viburnum opulus) may be considered a functional herb which processes cytoprotective activity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells by Zakłos-Szyda M1, Pawlik N2, Polka D2, Nowak A3, Koziołkiewicz M2, Podsędek A. (PubMed)




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