Tuesday, 15 January 2019

Phytochemical Piperine, the Bioactive Compound May Process Anti Asthmatic Potency, Scientists Suggest

By Kyle J. Norton

Scientists may have found a natural compound for the prevention and treatment of asthma with no side effects, according to the studies.

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing.

According to the statistics, in Canada, the number of people with asthma continues to grow. One in 12 people or 8% of the population had asthma in 2009, compared with 1 in 14 (about 20 million, or 7%) in 2001.

Asthma attacks had affected over 53% of people with asthma, compared to 57% in children in 2008.

Signs and symptoms of asthma can be triggered by airborne substances, such as pollen, dust mites, mold spores, pet dander or particles of cockroach waste. Respiratory infections, such as the common cold also be found to be the major contribution of asthma in children.

Although, researchers do not know why? people with the same health conditions in the same family, some are susceptible to the onset of asthma, while others do not. However, researchers do know, family history, race, being obese or obese, having another allergic disease, being a smoker, long-term exposure to smoking and irritable chemicals are at the increased risk of asthma development.

Dr. Mahdi Bijanzadeh, the lead scientist in the summary of " An understanding of the genetic basis of asthma" wrote, in the "Asthma is the most common chronic childhood disease in developed nations and its prevalence has increased in the world over the last 25 years. It is a complex disease with both genetic and environmental risk factors. Asthma is caused by multiple interacting genes, some having a protective effect and others contributing to the disease pathogenesis, with each gene having its own tendency to be influenced by the environment".

These results firmly suggested that people inherited a mutated gene from their parent may also be at a higher risk of the disease. 

According to Medscape, the 10 genes (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ, ORMDL3, IL2RB, SLC22A5, IL13, and RORA), 6 of which were confirmed by EVE investigators (IL1RL1/IL18, TSLP, IL33, SMAD3, HLA-DQ and ORMDL3).{Re9} 10 genes have been identified with strong association with the onset of asthma.

Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.

On finding a natural bioactive compound or whole food for the treatment of asthma, researchers at the JSS College of Pharmacy, Rocklands, examined the different plant extracts and phytoconstituents with the proven anti-asthmatic property.

Piper Longum L. Extract (20% Piperine) demonstrated a significant effect against human pathogens causing upper respiratory infection namely Haemophilus influenza, Streptococcus pneumonia, Streptococcus pyrogen, and Staphylococcus aureus.

Furthermore, researchers examined the effects of increasing levels of antioxidant in asthmatic patients against continued oxidative stress to determine the hypothesis of boosting the antioxidant defenses of asthma patient that could be beneficial as it may help thwart symptoms of lung disease and asthma.

The results of the experiment are astonishing.

Piper longum extracts at the same concentration of 20% piperine or piperine at 98% concentration, displayed a potent antioxidant activity by Nitric oxide radical inhibition activity method.

Dr. Nilani P, the lead scientist, after taking into account co and confounder, said, "Piper longum extract (20% Piperine),..... and piperine (98%) could be utilized in alternate anti-asthmatic therapy, since they play a vital role in scavenging Nitric oxide which could prevent the bronchial inflammation in asthmatic patients.".

The finding suggested that piperine processed anti-asthmatic property through its antioxidants and antibacterial activity. 

Taken altogether, piperine may be considered a bioactive compound for the prevention and combined with the primary therapy for treatment of asthma, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Effect of selected antiasthmatic plant constituents against micro organism causing upper respiratory tract infection by Nilani P, Duraisamy B, Dhamodaran P, Ravichandran S, Elango K.(PubMed)
(2) Invitro antioxidant activity of selected antiasthmatic herbal constituents by Nilani P, Kasthuribai N, Duraisamy B, Dhamodaran P, Ravichandran S, Ilango K, Suresh B.(PubMed)
(3) An understanding of the genetic basis of asthma by Mahdi Bijanzadeh, Padukudru A. Mahesh,* and Nallur B. Ramachandra. (PMC)
(4) Genetics of Asthma. Updated: Aug 05, 2015. Author: Scott T Weiss, MD, MS; Chief Editor: Karl S Roth, MD more...(Medscape)

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