Scientists may have found a bioactive compound for the prevention and treatment of oral cancer with no side effects, according to studies.
Oral cancer is any malignant cell growth in the tissue located in the oral cavity, including the tissue of the lips or the tongue, cheek lining, floor of the mouth, gums (gingiva) and the roof of the mouth (palate).
Most cases of oral cancer start in the cells on the surface of the inner lining of the oral cavity.
At stage 0 and 1, patients may not experience any symptoms as the cancer is localized in the outermost layer of tissue in the oral cavity or oropharynx less than 2 cm across.
* Among tonsil-related cancers (palatine tonsil and base of tongue) viral DNA was detected in 43% of cases (nine out of 21).
* The OR for tonsil-related cancers for high-risk HPV types was 19.32.
The medical plant has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia, swollen lymph nodes, leprosy, bronchitis, sore throats, tuberculosis, chicken pox, etc.
Besides the main ingredient andrographolides, giving the plant a bitter taste, other ingredients of herbal Andrographis include diterpene lactones, neoandrographolide, andrographiside, 14-doexy-11, 12-didehydro andrographolide, etc., flavonoinds viz., oroxylin, wogonin, andrographidines A, B, C, D, E, F.
On finding a natural ingredient for the treatment of oral cancer with no side effects, researchers examined the effects of Andrographolide (Andro) isolated from an herbal plant, Andrographis paniculata.
Injection of Andro potently suppressed squamous cell carcinogenesis induced by 7,12-dimethyl-1,2-benzanthracene (DMBA) in the hamster model of cheek buccal pouch.
And, Andro inhibited cancer growth progression through a series of mechanisms, including inhibition of proteins that involved in cell growth, survival, development, and differentiation (such as Janus tyrosine kinases-signal transducers and activators of transcription, phosphatidylinositol 3-kinase and NF-κB signalling pathways) and cell division through activation of genes (p53 and p21) that are associated with tumor suppression.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Andrographolide inhibits oral squamous cell carcinogenesis through NF-κB inactivation by Wang LJ, Zhou X, Wang W, Tang F, Qi CL, Yang X, Wu S, Lin YQ, Wang JT, Geng JG. (PubMed)
(2) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. by Lim JC, Chan TK, Ng DS, Sagineedu SR, Stanslas J, Wong WS(PubMed)
(3) Human papillomavirus infection and oral cancer: a case-control study in Montreal, Canada by Pintos J1, Black MJ, Sadeghi N, Ghadirian P, Zeitouni AG, Viscidi RP, Herrero R, Coutlée F, Franco EL. (PubMed)