Scientists may have found a natural and single ingredient for the prevention and treatment of gastric cancer with no side effects, according to the studies.
Gastric cancer is a condition caused by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
At the later stage, liver cancer cells may travel a distance away from the liver to infect other healthy tissue, leading to secondary metastasis through blood and fluids circulation.
According to the American Cancer Society, every year, approximately 26,000 cases of stomach cancer will be diagnosed (16,000 in men and 9,000 in women). The cancer causes the death of over10,000 people, including 6,000 men and 4,000 women).
The cause of gastric cancer is a result of the alternation of cell DNA in the stomach. Researchers do not know what causes the cell DNA alternation, but they do know certain risk factors such as smoking, family history, genetic preposition, certain diseases associated with the stomach and previous stomach surgery are involved the onset of the disease.
However, some researchers suggested that infection caused by Helicobacter pylori is the most important risk factor for gastric cancer.
Dr. Lydia E. Wroblewski, the lead author examined the effects of Helicobacter pylori in the risk of gastric cancer wrote, "Helicobacter pylori is a gastric pathogen that colonizes approximately 50% of the world's population. Infection with H. pylori causes chronic inflammation and significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer".
And, "Infection with H. pylori is the strongest known risk factor for gastric cancer, which is the second leading cause of cancer-related deaths worldwide".
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
With an aim to find the natural compound for the treatment of gastric cancer with no side effects, researchers evaluated the allicin, an active compound derived from garlic anti-cancer effects.
Allicin injection reduced cell viability in a dose- and time-dependent manner, partly through induction of apoptosis in gastric cancer cells.
At the molecular level, allicin induced cancer death through degradation of cancer cells through activation of the proteins associated with the stimulation of cell apoptosis, including the caspase-3, -8, and -9 and Bax and fas expression.
In a total of patients with progressive gastric adenocarcinoma, whose diagnosis was by gastroscopy and pathological examination assigned to 2 groups, 40 in each group, researchers examined the effects of local application of allicin via gastroscopy on progressive gastric carcinoma.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
(3) Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk by Lydia E. Wroblewski,1,* Richard M. Peek, Jr.,1,2,3 and Keith T. Wilson. (PMC)