Sunday, 13 January 2019

Herbal Arnica, Speed Up Wound Healing with No side Effects

By Kyle J. Norton

Scientists may have found a natural plant for speeding up wound healing with no side effects, according to studies.

Wound healing is a natural process to restore the damage of injured tissue.

There are number stages of wound healing. The first and second phases are to stop bleeding and protect the tissue against infection through proteins associated with the production of blood palettes to cover the wound and inflammatory cytokines to kill off all the invasive pathogens, respectively.

The third phase is the proliferation phase in which the wound is filled, the margin of the wound is reduced and the wound is completely covered.

The 4 phase is the maturation phase in which the new tissue slowly recover the strength and flexibility.

However, any interruption of the wound healing processes such as untreated overproduction of inflammatory cytokines, reduced or inadequate blood supply to the wound can lead to the formation of scars or chronic wound.

According to the statistic, in the US,  6.5 million people suffer from wounds that are not properly healing, Chronic wounds are more common in elderly people or people with high blood pressure, obesity, particularly in people with diabetes.

If you have a wound that does not heal in a specific time frame, please check with your doctor right the way.

Dr. Krister Järbrink and colleagues in the examined the complications of chronic wounds wrote, " Complications of chronic wounds include infection such as cellulitis and infective venous eczema, gangrene, hemorrhage and lower-extremity amputations. Chronic wounds lead to disability and disability worsens wound outcomes resulting in a vicious cycle".

Herbal Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia. The plant has been used in herbal medicine for centuries to treat strains, sprains, and bruises.

Besides helenalin as it main ingredient used as an anti-inflammatory agent, the herb also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.

On finding the natural compound for the treatment of wound healing, researchers examined the composition of a herbal formula in topical formulations for the decrease of bruising and muscle pain in NIH 3T3 fibroblasts.

The ethanolic preparation contains the equal parts of Arnica montana 4x, Calendula officinalis 4x, Hypericum perforatum 4x and Symphytum officinale 6x (0712-2).

Preparation (0712-2) exerted a stimulating effect on fibroblast migration (31.9%) vs 14.7% with succussed solvent (0712-1) at 1:100 dilutions (p < 0.001).

Preparation (0712-2) at a dilution of 1:100 promoted in vitro wound closure by 59.5% and differed significantly (p < 0.001) from succussed solvent (0712-1), which caused 22.1% wound closure.

The findings suggested the formula exerts low potency in vitro wound closure potential in NIH 3T3 fibroblasts.

Furthermore, researchers at the Johann Wolfgang Goethe-Universität, Frankfur evaluated the Arnica D4 as efficacious as diclofenac in relation to symptoms and wound healing after foot surgery.

The randomized double-blinded, parallel-group study (GCP-standard), included Arnica D4 10 pillules (taken orally, 3 times per day) and diclofenac sodium, 50 mg (taken orally, 3 times per day) in 88 patients 4 days after hallux valgus surgery.

Arnica D4 and diclofenac were equivalent for wound irritation (lower margin of the 95% CI on day 4: 0.4729 for rubor; 0.3674 for swelling; 0.4106 for color) and patient mobility (0.4726).

Descriptive analysis showed the superiority of Arnica D4 with respect to patient mobility (p = 0.045). and pain, Arnica D4 was inferior to diclofenac (lower margin of the 95% CI 0.026). 

These results indicated that the efficacy of Arnica is compared to that of conventional medicine for the treatment of wound healing without inducing side effects. However, Arnica D4 is 60% cheaper than diclofenac.

Taken altogether, herbal Arnica may be used for the treatment of wound healing orally without inducing any side effects, pending a large sample size and multicenter study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) A homeopathic remedy from arnica, marigold, St. John's wort and comfrey accelerates in vitro wound scratch closure of NIH 3T3 fibroblasts by Hostanska K, Rostock M, Melzer J, Baumgartner S, Saller R.(PubMed)
(2) Efficacy of Arnica montana D4 for healing of wounds after Hallux valgus surgery compared to diclofenac by Karow JH, Abt HP, Fröhling M, Ackermann H.(PubMed)
(3) Effects of microcurrent application alone or in combination with topical Hypericum perforatum L. and Arnica montana L. on surgically induced wound healing in Wistar rats by Castro FC, Magre A, Cherpinski R, Zelante PM, Neves LM, Esquisatto MA, Mendonça FA, Santos GM. (PubMed)
(4) Prevalence and incidence of chronic wounds and related complications: a protocol for a systematic review by Krister Järbrink,1 Gao Ni,1 Henrik Sönnergren,2 Artur Schmidtchen,3 Caroline Pang,4Ram Bajpai,1 and Josip Car. (PMC)

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