Saturday, 19 January 2019

Phytochemical Phytic acid, the Potential Anti Diabetes Bioactive Compound, Scientists Find

By Kyle J. Norton

Scientists may have found a natural resource for the prevention and treatment of diabetes with no side effects, according to the studies.

Diabetes is a medical and chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

The diabetes is either caused by cells in pancreas died off due to the immune system mistakenly attacked the sell in the pancreas or receptor sites clogged up as a result of the excess fat and cholesterol in the bloodstream.

Researchers do not know why the immune system attacks its own tissue. Either they can explain people follow a lifelong intake of the Western diet, only some are susceptible to the onset of the disease, while others do not.

There are many risk factors such as age, ethnicity, family history, impaired glucose tolerance, insulin resistance, being overweight or obese and sedentary lifestyle. associated with the onset of the condition, epidemiologically. However, many people with some of the risk factors have never developed diabetes.

Some researchers suggested that unhealthy diet with high amounts of saturated and trans fat, red meat and processed foods and low amounts of fruits and vegetable as that of the Western diet is the most common risk factor of diabetes in the Western world.

Dr. David Hefner, in the concern of the Western diet in risk of diabetes, wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes".

And, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".

The results strongly suggested the risk of diabetes can be decreased with the change of diet pattern, from the Western diet to a healthy diet with high amounts of fruits and vegetables.

If you experience some of the belove symptoms such as increased thirst that can not be resolved by intake of liquid, frequent urination, extreme hunger, and unexplained weight loss, you may have type 2 diabetes. Please make sure you check with your doctor to rule out the possibility.

Phytic acid (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

On finding a natural bioactive compound for the treatment of diabetes with no side effects, researchers examined the effect of the phytic acid supplement on streptozotocin-induced diabetic rats.

Diabetic rats were fed rodent chow with or without phytic acid supplementation for thirty days. According to the assay used for the experiment, phytic acid supplement treated group showed an increase in average food intake and a decrease in body weight gain compared to the diabetic and normal control groups.

Compared to other groups, phytic acid supplement treated group also exerted a downtrend in intestinal amylase activity. The spike in random blood glucose in the treatment group also lower compared to others.

Furthermore, the treatment group also displays reduced serum triglycerides and increased total cholesterol and HDL cholesterol levels and levels of serum alkaline phosphatase and alanine aminotransferase activities, the indication of improvement of insulin sensitivity.

Moreover, levels of pro-inflammatory cytokines also lower in phytic acid supplement treated group compared to other groups.

Dr.Omoruyi FO, the lead scientist at the end of the study, wrote, "phytic acid supplementation may be beneficial in the management of diabetes mellitus".

Additionally, researchers randomly assigned six groups of rats fed to test the anti-diabetes of phytic acid, for 3 weeks as follows: 
* Groups 1 and 2 were fed formulated diets supplemented with zinc or without zinc respectively. 

* Groups 3 and 4 were fed formulated diets supplemented with zinc plus phytic acid extracted from sweet potato (Ipomea batatas) or commercial phytic acid respectively. 

* Groups 5 and 6 were fed formulated diets supplemented with a phytic acid extract from sweet potato or commercial phytic acid respectively. 

At the final day of the experiment, researchers found that phytic acid extract consumption from sweet potato and commercial phytic acid plus zinc supplement lowered blood glucose levels.

However, phytic acid supplementation showed no significant decrease in the activity of pyruvate kinase involved in the insulin stimulation of this enzyme activity, compared to the group fed formulated diets.

Groups fed phytic extract from sweet potato also exerted a significant increase in the activity of glucose-6-phosphate dehydrogenase in the promotion of pancreatic beta-cell function, compared to the other groups.

Taken altogether, phytochemical phytic acid may be used for the prevention and combined with the primary medicine for the treatment and management of type 2 diabetes.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats by Omoruyi FO1, Budiaman A1, Eng Y1, Olumese FE2, Hoesel JL3, Ejilemele A3, Okorodudu AO (PubMed)
(2) The effect of phytic acid on the levels of blood glucose and some enzymes of carbohydrate and lipid metabolism by Dilworth LL, Omoruyi FO, Simon OR, Morrison EY, Asemota HN(PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (NMA)

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