Allicin, the bioactive ingredient isolated from garlic may have a profound effect on the prevention and treatment of high blood cholesterol with no side effects, according to studies.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Hyperlipidemia is a condition characterized by abnormally high blood cholesterol in the bloodstream. In other words, the levels of low-density lipoprotein (LDL) are high compared to the high-density lipoprotein (LDL) in the blood.
The ideal blood cholesterol is less than 4 (levels of LDL)/ 1(levels of HDL).
Low-density lipoprotein is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However, overexpression of LDL can induce plaque accumulated on the arterial wall, leading to atherosclerosis, a major cause of cardiovascular disease.
Low-density lipoprotein is produced by the liver or from the dietary sources. High-density lipoprotein neutralizes the levels LDL by returning them to the liver.
In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not in reducing blood cholesterol, triglycerides, and glucose levels, as well as lowering the hepatic cholesterol storage, but also decreasing appetite daily.
Other in the study of the same but with rat fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats. These result showed that allicin may be considered as a potent agent in treating hyper cholesterol in the future.
On finding a natural ingredient for the prevention and treatment of high blood cholesterol, a widespread syndrome found in the Western world, researchers investigated the cholesterol-lowering properties of allicin, a bioactive compound isolated from garlic.
Furthermore, allicin showed a strong effect in reducing blood cholesterol, triglycerides, and glucose levels and caused a significant decrease in lowering hepatic cholesterol storage.
* Serum triglyceride levels were also significantly lowered by garlic powder when compared to control and high cholesterol diet group rats.
* The blood pressure of the high cholesterol diet animals was significantly higher compared to the animals receiving the control diet.
* The blood pressure of the animals receiving garlic powder and high cholesterol diet was significantly lower as compared to the high cholesterol and control diet group.
Once again, garlic with high amounts of allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
(3) Diet Modification for Hyperlipidemia. Individual approach to diet planning and education by Heather D. Mann and Pamela Piotrowski. (PMC)