Scientists may have found a herbal medicine for the prevention and treatment of type 4 hypersensitivity with no side effects, according to studies.
Type 4 allergy or type 4 hypersensitivity is often called delayed-type hypersensitivity as the reaction takes several days to develop.
Arctostaphylos uva-ursi is one of the species of Bearberry, in the genus Arctostaphylos, belonging to the family Ericaceae, native to northern North America, Asia, and Europe.
The herb has been used in traditional medicine as a diuretic agent and to treat urinary problems, including bladder infections, kidney infection, kidney stone, pelvic pain, etc.
The herbal plant contains arbutin, ursolic acid, tannic acid, gallic acid, some essential oil and resin, hydroquinones tannins, phenolic glycosides, and flavonoids.
In the concern of the widespread of Type IV hypersensitivity caused by the contact dermatitis, researchers at the Kinki University examined the combined effect of arbutin isolated from the leaves of Arctostaphylos uva-ursi (L.) Spreng. (Bearberry leaf) and indomethacin on Type IV allergic reaction-induced immuno-inflammation, carrageenin-induced edema, and adjuvant-induced arthritis.
Researchers at the above studies wrote in the final report, "Bearberry leaf possesses a therapeutic effect against immuno-inflammation induced by PC-CD and also increases the inhibitory effect of prednisolone, and its active principle may be arbutin".
Taken altogether, herbal Herbal Arctostaphylos uva-ursi (Bearberry) may be considered a functional remedy for the prevention and combined with primary medicines for the treatment of type 4 hypersensitivity with no side effects.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. V. Effect of water extract from Arctostaphylos uva-ursi (L.) Spreng. (bearberry leaf) on the antiallergic and antiinflammatory activities of dexamethasone ointment].[Article in Japanese] by Matsuda H, Nakamura S, Tanaka T, Kubo M.(PubMed)
(2) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. III. Combined effect of arbutin and indomethacin on immuno-inflammation].[Article in Japanese] by Matsuda H, Tanaka T, Kubo M.(PubMed)
(3) [Pharmacological studies on leaf of Arctostaphylos uva-ursi (L.) Spreng. I. Combined effect of 50% methanolic extract from Arctostaphylosuva-ursi (L.) Spreng. (bearberry leaf) and prednisolone on immuno-inflammation].[Article in Japanese] by Kubo M, Ito M, Nakata H, Matsuda H.(PubMed)