Tuesday, 8 January 2019

Phytochemical Indole-3-carbinol, the Potent Anti Prostate Cancer Plant Base Compound

By Kyle J. Norton

Scientists may have found a bioactive compound isolated from the cruciferous vegetable for the prevention and treatment of prostate cancer with no side effects, according to studies.

Indole-3-carbinol is a phytochemical in the class of Indoles, by the breaking down of the glucosinolate glucobrassicin, found abundantly in cabbage, kale, Brussels sprouts, rutabaga, mustard greens, broccoli, etc.

Prostate cancer is a medical and chronic condition in which the cells of the prostate has become cancerous due to the alternation of the cells DNA.

Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the Physical (rectum) exams.

Primary prostate cancer normally starts from the cell on the surface of the inner lining of the prostate tissue and gradually spread to the deeper part of the prostate.

At the early stage, patients may not experience any symptoms, However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine, frequent urination and urinary difficulty.

The cancer cells at this stage can also travel a distance away from the prostate to invade other healthy tissue and organ, leading secondary metastasis tumors.

According to the statistic, the 5-year survival rate for local and regional (stage 0 and 1) stages prostate cancer is nearly 100%.

Therefore, men who are at higher risk of prostate cancer due to family history and increase in age and inherited gene changes should have their prostate gland checked annually.

Believe or not, more than 80% of prostate cancers are diagnosed in men who are 65 or older.

Dr. Roberto Fabiani, the lead scientist at the University of Perugia suggested that people who follow the Western diet pattern are at increased risk of prostate cancer onset.

According to the results from the review of 12 observational studies included in the meta-analysis which identified a “Healthy pattern” and a “Western pattern”, he said, "The Healthy pattern was not related to PC risk (OR = 0.96; 95% confidence interval (CI): 0.88–1.04) while the Western pattern significantly increased it (OR = 1.34; 95% CI: 1.08–1.65)".

In other words, by a change of diet from high in saturated and trans fat, red meat and processed foods to diet high in fruits and vegetables and whole grain,  the risk of prostate cancer can be reversed.

In order to reaffirm the epidemiological evidence which suggested that intake of cruciferous vegetable intake is associated with a reduced risk of prostate cancer, researchers at the Oregon State University, Corvallis assessed the bioactive compound indole-3-carbinol against the onset of prostate cancer.

In vitro and in vivo. application of indole-3-carbinol inhibit prostate cancer by both blocking initiation and suppressing prostate cancer progression. these results were associated with the induction of phases I and II detoxification pathways.

Injection of indole-3-carbinol inhibited the cell signaling pathways associated with cancer cells proliferation and survival.

Recently, indole-3-carbinol derivatives induced cancer cytotoxicity through induction of free radical expression.

In the laboratory, I3C can induce G1 cell-cycle arrest and apoptosis in prostate cancer cells. 

Futhermore, I3C and its derivative dimeric product 3,3'-diindolylmethane (DIM) inhibited the genes associated with the control of cell cycle, cell proliferation, signal transduction, and other cellular processes in prostate cancer cell lines.

Dr. Sarkar FH, the lead scientist, wrote in the final report of the experiment, "Because there is no effective treatment strategy for hormone-dependent and, most importantly, hormone-independent and metastatic prostate cancer, our strategies to sensitize prostate cancer cells to a chemotherapeutic agent by I3C and DIM is a novel breakthrough that could be used for devising novel therapies for prostate cancer".

More importantly, Wayne State University School of Medicine, in the study to confirm that a diet rich in fruits and vegetables provides phytochemicals, launched an investigation to examine the anticancer effect of indole-3-carbinol (I3C).

According to the study, I3C inhibits the growth of PC-3 prostate cancer cells
* through the Induction of G1 cell cycle arrest.

* Promoted the expression of regulators associated with cell cycle progression at G1 and S phase and proteins associated with cancer cell apoptosis.

* Inhibited proteins associated with the progression of cell cycle division

* Inhibited protein in the promotion of proteins associated with cancer cell cycle division.

Taken altogether, the plant base  Indole-3-carbinol isolated from the cruciferous vegetable may be used for the prevention and treatment of prostate cancer with no side effects.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. by W Watson G1, M Beaver L, E Williams D, H Dashwood R, Ho E.(PubMed)
(2) Indole-3-carbinol and prostate cancer by Sarkar FH1, Li Y. (PubMed)
(3) Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells by Chinni SR1, Li Y, Upadhyay S, Koppolu PK, Sarkar FH.(PubMed)
(4) Indole-3-carbinol and 3',3'-diindolylmethane modulate androgen's effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells by Kim EK1, Kim YS, Milner JA, Wang TT. (PubMed)
(5) A Western Dietary Pattern Increases Prostate Cancer Risk: A Systematic Review and Meta-Analysis by Roberto Fabiani,1,* Liliana Minelli,2 Gaia Bertarelli,3 and Silvia Bacci. (PMC)

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