Friday, 1 December 2017

Herbal Therapy: Green Tea, The Nano-Beverage for Treatment of Ovarian Cancer

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Green tea may have a potential effect in reduced risk and treatment of ovarian cancer, some institute studies suggested

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Ovarian cancer is a medical condition characterized by cell growth disorderly in the ovaries. At the late stage, cancerous cells may infect tissues and organs far away from the originated site.

In the analysis of the EGCG effects on 8 ovarian cancer cell lines (SKOV3, CAOV3, OVCAR3, OVCAR10, A2780, CP70, C30, and C200) and showed IC50s for EGCG at the micromolar range, researchers found that EGCG inhibited all ovarian cancer cell lines in dose depending manner.

Normal dose application of EGCG displayed a significant increase of antioxidant in reduced ROS over expression of oxidative stress in inhibited ovarian cancer through cell cycle arrest in G2/M phase.

Further differentiation also revealed that administration of EGCG at common dose not only demonstrated a 6 fold increase of cisplatin potency for treatment of SKOV3, CAOV3, and C200 cells, but also attenuated the chemodrug toxicity.

However, the effect of EGCG on the formation of reactive oxygen species (ROS) was biphasic.
The phytochemical was shown to induce and decrease ROS formation in different doses.

Therefore, higher dose of EGCG promoted over expression of antioxidants in reduced oxidative stress may amplify the toxicity in ameliorated human cancer cells proliferation and induced apoptosis.

Dr., the lead author said, "EGCG may accentuate oxidative stress to inhibit growth of ovarian cancer cells and sensitize them to cisplatin".

Other researchers in the study of toxicity of EGCG suggested that green tea catechin, (-)-epigallocatechin-3-O-gallate (EGCG) as a potent adjuvant to enhance the anti tumor efficacy of cisplatin while mitigating its harmful side effects through various mechanisms.

Application of EGCG showed to promote hyaluronic acid function in regulation of normal cell division and prevention of the acid in initiation of cancerous cell proliferation.

Hyaluronic acid, a polysaccharide molecule, plays an important role in cell proliferation and migration, and may involve in the progression of some malignant tumors.

Additionally, EGCG also expressed anti cancer effect by promoting the injection of chemo medicine cisplatin into the CD44-over expressing cancer cells to prevent over growth of tumor cells.

In regard to toxicity, EGCG on one hand, reduced over expression of oxidative stress in initiated toxicity against off-target organs and tissues through induction of a significant antioxidant activity on the hand, and stimulated function of toxicity originating from cisplatin into the target tumors on the other..

Further analysis, green tea catechin-based micellar nanocomplexes also inhibited superiorly against tumor growth with no injection of cisplatin and expressed a significant inhibition without induced toxicity in both cancer cells suspended in culture medium and injected into the animal models and peritoneal metastatic model of human ovarian cancer.

In other words, green tea catechin-based micellar nanocomplexes may be considered as a safe and effective cisplatin nanomedicine for ovarian cancer treatment..

More interestingly, in the additionally examined the effect of EGCG in suppressing ovarian cancer cell growth in 3 human ovarian cancer cell lines (p53 negative, SKOV-3 cells; mutant type p53, OVCAR-3 cells; and wild type p53, PA-1 cells),

EGCG decreased tumor growth in each cell line in a dose-dependent fashion and induced apoptosis and cell cycle arrest, particular to the G(1) phase in SKOV-3 and OVCAR-3 cells in compared to G(1)/S transition phase arrest in PA-1 cells.

The chemical also differentiately upregulated the expression of genes and proteins in promoted cancer cell arrest, suppressed tumor growth and induced cell death (Bax, p21, Retinoblastoma, cyclin D1, CDK4, Bcl-X(L)) by more than 2-fold

Taking altogether, green tea may have a profound effect in reduced risk and treatment of ovarian cancer through expression of phytochemical EGCG. However, intake of green tea extract must be taken with care, as overdoses were found to induce liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Hyaluronic acid-green tea catechin micellar nanocomplexes: Fail-safe cisplatin nanomedicine for the treatment of ovarian cancer without off-target toxicity by Bae KH1, Tan S1, Yamashita A1, Ang WX1, Gao SJ1, Wang S1, Chung JE1, Kurisawa M2.(PubMed)
(2) Epigallocatechin-3-gallate delivers hydrogen peroxide to induce death of ovarian cancer cells and enhances their cisplatin susceptibility by Chan MM1, Soprano KJ, Weinstein K, Fong D.(PubMed)
(3) Anticancer effects of (-)-epigallocatechin-3-gallate on ovarian carcinoma cell lines by Huh SW1, Bae SM, Kim YW, Lee JM, Namkoong SE, Lee IP, Kim SH, Kim CK, Ahn WS.(PubMed)

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