Colon cancer is a medical condition caused by cell growth disorderly and uncontrollably in the colon tissues. At the later stage, the cancerous cell may travel a distance away to infect other healthy organs and tissues.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
In the review of medical literature published online, green tea efficacy in reduced risk and treatment of colon cancer may be associated to the bioactive polyphenol EGCG expression in promoted and
decreased certain interaction in the cell profiles through various mechanisms.
According to the study by the University College of Medicine, Seoul, application of EGCG on HT-29 colon cancer cells showed a significant effect in inhibition of cell cycle progression of protein in COX-2 expression. through activation of AMPK activity in promoted metabolic tumor suppressor by regulating energy levels, enforcing metabolic checkpoints and inhibiting cell growth.
Cyclooxygenase(COX)-2, is an enzyme with function in speeding up the production of hormone prostaglandins in regulated cell proliferation and cell apoptosis.
AMPK(5' AMP-activated protein kinase) plays a role in cellular energy homeostasis, activation of AMPK may result in tumor growth inhibition, cell cycle arrest, and apoptosis of cancer cells in some tumor types/contexts.
Further analysis, application of EGCG activated AMPK enzyme also modulated the production of ROS without causing ROS expression in initiated tumor progression and damage to cellular structures, such as the lipid membrane, protein and nucleic acid but inducing cancer cells DNA mutations and compromised genome integrity, subsequently in cancer cells senescence and death.
In other aspect of study of colon cancer in animal model, diminished levels of retinoid X receptor-alpha (RXRα) in regulated cancer cell growth and modulated suppress tumorigenesis may have a profound effect in cell proliferation.
Application of green tea bioactive EGCG expressed a significant effect in restored RXRα protein and expression levels caused by methylation function in alternated the activity of a DNA segment without changing the sequence, thus reducing risk of cancer expansion.
Additional differentiation also suggested that EGCG induced methylation changes in several other colon cancer related genes to restore the levels of RXRα without causing a decrease in global methylation in maintaining the epigenetic state of individual genes.
Change of globe methylation expression is found to associate to the occurrence of cancer.
Retinoid X receptor-alpha (RXRα) is a nuclear receptor with function in regulated cancer proliferation and modulated suppression of tumorigenesis.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway by Hwang JT1, Ha J, Park IJ, Lee SK, Baik HW, Kim YM, Park OJ.(PubMed)
(2) Reduction in promotor methylation utilizing EGCG (epigallocatechin-3-gallate) restores RXRα expression in human colon cancer cells by Morris J1, Moseley VR2, Cabang AB1, Coleman K2, Wei W3, Garrett-Mayer E4, Wargovich MJ1.(PubMed)
(3) Global Methylation in Exposure Biology and Translational Medical Science by Heather H. Nelson,1,2 Carmen J. Marsit,3,4 and Karl T. Kelsey4,5(PubMed)