Eggplant is a species of S. melongena with deeply purple color, belongings to the family Solanaceae and native to India, cultivated in southern and eastern Asia since prehistory.
Melanoma cancer is medical condition characterized by irregular cell growth in the issues of skin. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistic, approximately 87,110 new cases of invasive melanoma caner will be diagnosed in the U.S. in 2017.
The investigated the glycoalkaloids isolated from numerous Solanaceous plants, including eggplant in risk of melanoma, suggested that eggplant glycoalkaloids derivatives α-solamargine and α-solasonine demonstrated a significant effect in inhibition of cancer cells proliferation, in both vitro and vivo.
Further analysis of the chemistry and structure-activity also suggested that both α-solamargine and α-solasonine exert a strong antioxidant effect in increased cancer cell apoptosis and decrease tumor formation through expression of mitogen-activated protein kinase (MAPK) in cancer cellular processes and NF-kappaB cascades in enhanced T-cell development, maturation, and proliferation, in animal models.
inhibition of the growth of metastatic and primary melanoma cell lines WM239 and WM115 with minimum effect on normal and benign WM35 melanoma cells through reduced blood supplies in induced necrosis by rapid induction of lysosomal membrane permeabilization in controls the passage to allow intracellular or intraorganellar antigens into and out of lysosomes.
Additionally, the suppression of tyrosinase, TRP-1, and TRP-2 expression also attenuated
alpha-melanocyte-stimulating hormone in production of melanogenesis in B16 cells.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Chemistry and anticarcinogenic mechanisms of glycoalkaloids produced by eggplants, potatoes, and tomatoes by Friedman M1.(PubMed)
(2) Dioscin Derived from Solanum melongena L. "Usukawamarunasu" Attenuates α-MSH-Induced Melanogenesis in B16 Murine Melanoma Cells via Downregulation of Phospho-CREB and MITF by Nishina A1, Ebina K1, Ukiya M1, Fukatsu M1, Koketsu M2, Ninomiya M2, Sato D3, Kimura H4.(PubMed)
(3) Solamargine triggers cellular necrosis selectively in different types of human melanoma cancercells through extrinsic lysosomal mitochondrial death pathway by Al Sinani SS1, Eltayeb EA1, Coomber BL2, Adham SA1.(PubMed)