Green tea may have a therapeutic and positive effect in reduced risk and treatment of pancreatic cancer, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Pancreatic cancer is medical condition characterized by irregular cell growth in the issues of pancreas. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistic, the average lifetime risk of pancreatic cancer for both men and women is about 1 in 65.
In human pancreatic ductal adenocarcinoma (PDAC) cell lines PancTu-I, Panc1, Panc89 and BxPC3, to compare the inhibited effect of EGCG to 2 components of catechins, namely, catechin gallate (CG) and epicatechin gallate (ECG), application of green tea 2 catechins components demonstrated a strong effect in inhibited proliferation of PDAC cells in a dose- and time-dependent manner.
In comparison test, green tea CG and ECG exerted much stronger anti-proliferation effects than those of EGCG.
Additionally, all 3 components of green tea catechins also demonstrated a substantiated effect in ameliorated secretion of pro-inflammatory and invasion promoting proteins of the cancer cell through expression of TNF tumor necrosis factor in activated of the nuclear factor NF-κB protein signalling involved mediation of DNA transcript, pro inflammatory cytokines production and cancer cell survival.
Tumor necrosis factor is a cell signaling protein possessed a wide range of proinflammatory actions
NF-κB is a protein with function in controlled transcription of DNA, cytokine production and cell survival.
In human pancreatic cancer cells lines MIA PaCa-2 cells, injection of green tea EGCG plus Bleomycin, (BLM), an anti-cancer chemotherapeutic drug displayed a substantial effect in inhibited cell proliferation through cell cycle transition phase arrest and mitochondrial depolarization by mitochondrial permeability transition in induction of cell apoptosis, after 72 hours.
Additional examination, indicate that EGCG and BLM exhibited anti-proliferative effects significantly in induced apoptosis of MIA PaCa-2 cells and suggested that this combination could represent a new strategy with potential advantages for treatment of pancreatic cancer.
In pancreatic cancer cell lines MIA PaCa-2 and PANC-1, injection of pterostilbene isolated from blue berry and EGCG expressed a strongly additive antiproliferative effect after 72 hours with MIA underwent S-phase arrest but not in cancer cell line PANC-1.
Both pterostilbene and EGCG induced mitochondrial depolarization in enhanced cytochrome c released from mitochondria to trigger programmed cell death during the early stages of apoptosis was observed also in MIA, but not in PANC
Taking altogether, green tea with abundant antioxidant catechins may be used as adjunct therapy for reduced risk and combined standard medicine for treatment of pancreatic cancer.
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
FOOD HACK for Weight Loss
A Simple Cooking Technique That Cuts The Calories & Glycemic
Impact In Rice, Pasta, And Potatoes In Half
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. by Kürbitz C1, Heise D, Redmer T, Goumas F, Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A.(PubMed)
(2) Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancerMiaPaca-2 cell growth by Bimonte S#1, Leongito M#1, Barbieri A2, Del Vecchio V2, Barbieri M1, Albino V1, Piccirillo M1, Amore A1, Di Giacomo R1, Nasto A1, Granata V3, Petrillo A3, Arra C2, Izzo F1.(PubMed)
(3) Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro by Kostin SF1, McDonald DE, McFadden DW.(PubMed)