Lectin isolated from lentils and other sources may have a substantial effect used for treatment of cancers and as a new type of potential biomarkers and therapeutic targets to detect the state and progression of prostate cancer, some scientists suggested.
Lentil, a type of pulse or tiny legumes that can be cooked quickly and rich in protein and fiber is a bushy annual plant of genus Lens the Fabaceaefamily, native to Middle East.
Prostate cancer is a chronic and medical condition characterized by cell growth irregularly in the prostate tissues.
Use of lectins with properties of recognizing specific carbohydrate moieties of glycoconjugates (for
carbohydrates covalently linked with other chemical species such as proteins, peptides, lipids and saccharides) as cancer screening technique and biomarkers to indicate altered structural changes of glycans in complex bodily fluids and tissues of cancer have been under extensive research.
According to the Indian Institute of Chemical Biology 4, in a designed to distinguish prostate cancer and benign prostate hyperplasia by lectin-prostate specific antigen (PSA) binding found that lectin-prostate specific antigen (PSA) binding may be an effective tool in reduced performance of biopsies in men with total PSA value between 4.0 to 10.0 micog/ml, through examine the carbohydrate content after binding of Con A (lectin) with serum PSA of prostate cancer.
The contradictory results in influence on prostate cancer cell proliferation, probably was attributed to types of lectin isolated and doses exposure.
After taking into account of other con-founders, Dr. Isabelle Camby, the lead author concerned, "because lectins are present in our diet, and are able to pass into the systemic circulation and thus reach the prostate, the present results suggest that some lectins might exert an influence on prostate cancer growth under clinical conditions".
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Lectin-induced alterations on the proliferation of three human prostatic cancer cell lines by Isabelle Camby, Thierry Janssen, Robert De Decker, Michel Petein, Gil Raviv, Jean-Lambert Pasteels, Robert Kiss, André Danguy(Sprinker link)
(2) Lectin and serum-PSA interaction as a screening test for prostate cancer by Basu PS1, Majhi R, Batabyal SK.(PubMed)