Methanolic extract of Chick (Garden) Peas may have a potential effect in decreased platelet aggregation and inhibited thrombus formation, thus improving blood circulation for prevention of cardiovascular disease, some scientists suggested.
Garbanzo beans also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetable, native to Middle East.
Inflammation is a natural process of immune defense against infection caused by injure through removal of injurious agents, necrosed cells and tissues.
Evaluation of pea family effects in reduced platelet aggregation for prevention of cardiovascular disease have been found to associated to numbers of mechanisms involved many aspects.
Methanolic extract isolated from garden pea and Desi chickpea demonstrated an inhibited arachidonic acid (AA) expression in induction of platelet aggregation (IC50 = 35 microg/mL)
Arachidonic acid, an omega-6 unsaturated fatty acid with function in growth and repair of muscle tissue is also important as an proinflammatory and immunosupportive substance in response to actute and chronic tissue damage.
Prostaglandin H2 is a type of prostaglandin acted as mediators involved in physiological processes, including platelet aggregation, muscle movement and inflammation.
Further differentiated the other effects of methanolic extract isolated from garden pea and Desi chickpea on platelet aggregation, showed that the extract isolated from garden pea displayed a positive inhibition of platelet activating factor (PAF)(IC50 = 38 microg/mL) in a dose dependent fashion, in induction of platelet aggregation, but this action was not found in Desi chickpea extract.
Platelet-activating factor (PAF), is a lipid mediator with function in exhibited expression of platelet aggregation, immune response and inflammation.
The findings suggested that there must exist other mechanisms in reduced platelet aggregation, other than inhibition of arachidonic acid (AA) and platelet-activating factor (PAF) activities by the testing extract isolated from the above members of pea family.
Further differentiation showed that methanolic extract isolated from the pea family also inhibited platelet aggregation through endothelial cells COX-2 lining the interior surface of blood vessels and lymphatic vessels in production of platelet PGE2 precipitated by inflammatory cytokine expression during the acute phase of tissue damage.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpeaand Kabuli chickpea by Zia-ul-Haq M1, Khan BA, Landa P, Kutil Z, Ahmed S, Qayum M, Ahmad S.(PubMed)