Hepatic steatosis is a medical condition characterized by fat accumulation accompanied by a progressive inflammation of the liver.
The edible mushroom is a genus A. Muscaria and belongings to the family Amanitaceae and cultivated in many cultures all over the world for foods and health benefits.
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat.
However, too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place.
In ovariectomized (OVX) mice (a model of postmenopausal women) induced hepatic steatosis by a high-fat diet supplemented with WBM powder, researchers found that(1)
* Dietary WBM intake in tested mice significantly lowers liver weight and hepatic injury markers.
* Treated mice also shows less fat accumulation in the livers, according to liver tissue analysis.
Further analysis of microarray analysis also revealed that genes related to the fatty acid biosynthesis pathway, including the genes for fatty acid synthetase (Fas) and fatty acid elongase 6 (Elovl6), the enzymes which are responsible for lipogenesis (the metabolic formation of fat)(1) found to decrease in the liver of mushroom-fed mice.
Moreover, in a vitro mechanistic studies using the HepG2 cell line, scientists explained, the efficacy in reduced expression of FAS and ELOVL6 in liver fat formation was attributed to button mushroom property in inhibition of liver X receptor (LXR)(1) signaling in activated and promoted above genes.
Dr. Kanaya N, the lead author, after taking into account of other co and confounders said, "WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women".
However, further data collection on large example size and multi-center studies performed with human consumption of the whole food of button mushroom during the course of the disease will be necessary to complete the picture of anti-fatty liver possibilities.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
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Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Hepatic and Extrahepatic Insulin Clearance Are Differentially Regulated: Results From a Novel Model-Based Analysis of Intravenous Glucose Tolerance Data by David C. Polidori,1 Richard N. Bergman,2 Stephanie T. Chung,3 and Anne E. Sumner(PMC)