Tuesday, 11 September 2018

Green Tea and Its Bioactive Polyphenol EGCG Kill Bacteria That Cause Carbuncle

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of carbuncle, a skin disease, some scientists suggested.

Carbuncle is collection of boils developed under the skin caused by bacterial infection of  hair follicles in induction of swelling.

Although, the infections are most likely developing on the follicles of the hair, they can also appear on other areas of the body such as the buttocks, thighs, groin, and armpits.

Researchers suggested that people who are older age, obesity, poor hygiene, and poor health are most likely associated to increased risk of carbuncles. 

However,  chronic skin conditions, chronic kidney disease,.... and liver disease are also increased the prevalent risk the infection.

According to University of Miami School of Medicine, "Skin infections account for a significant portion of dermatologic disease, often resulting in or as a consequence of a disruption in the skin's integrity" and " The infections presented herein include impetigo, ecthyma, folliculitis, carbuncles/furuncles, cellulitis, toxic shock syndrome, and ecthyma gangrenosum"(4).

The differentiation hinted that people with carbuncle are also susceptible to other skin disease.

Green tea, is a precious drink processed numbers of health benefit known to almost everyone in Asia and Western world.

In the searching of the natural ingredient to replace the use of antibiotics in treatment of bacterial infection of carbuncle, researchers at the J the Rockefeller University  found that epigallocatechin-3-gallate isolated from green tea extracts exerts a significant effect in inhibited the activity of Staphylococcus aureus (S. aureus), a leading candidate in exhibited risk of carbuncle.


Further analysis also suggested that application EGCG inhibited the typhimurium type III protein effectors in restriction of bacterial invasion into tested cells.

The type III secretion system of Salmonella typhimurium is found to have a direct effect in  translocation of proteins into host cells in initiated infection.

Dr. Tsou LK, the lead authors said, "These results reveal additional dietary plant metabolites that can attenuate bacterialvirulence and infection of host cells".

Some researchers at the Mashhad University of Medical Sciences, after lenghty searching for effective agent without inducing intolerant adverse effect for treatment of bacterial infection, found that green tea catechins, the major green tea polyphenols, shows antimicrobial activity against resistant pathogens, including Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).

In compared of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates, inhibited bacterial activities by a minimum inhibitory concentration (MICs) of gentamicin in the range of 0.312 - 320 μg/mL and The MIC values of both types of catechins were 62.5 - 250 μg/ mL. in compared to no effect in methylxanthines  application.

Interestingly, the dose of gentamicin was reduced substantial if adding dose of green tea extract and cactechin according to the MICs.

These result indicated that green extract and major bioactive polyphenol catechin may be used alone or combined with gentamicin for treatment of bacterial infection, including carbuncle without inducing adverse effect.

Dr. Fazly Bazzaz BS, the lead scientist after taking into account of other co and confounders said, "green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains" and "combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance".

Additionally, the evaluate antibacterial activity of the Indonesian water soluble green tea extract, Camellia sinensis, against clinical isolates of methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA) and multi-drug resistant Pseudomonas aeruginosa (MDR-P. aeruginosa conducted by theUniversity of Indonesia suggested
* The inhibition zone diameters of green tea extracts for S. aureus ATCC 25923 and MRSA were 18.970 ± 0.287 mm, and (19.130 ± 0.250) mm respectively.

* The inhibition zone diameter for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were (17.550 ± 0.393) mm and (17.670 ± 0.398) mm respectively.

*The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 µg/mL and 400 µg/mL, respectively.

And
* The MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were 800 µg/mL, and 800 µg/mL, respectively.

Taking altogether, green tea extract and its bioactive polyphenol catechin may be considered as a functional food in reduced risk and treatment of carbuncle caused by Staphylococcus aureus (S. aureus).

Howvwer, intake of green tea extract should be taken with extreme care as acute liver toxicity has been reported by numbers of medical literature.

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Author Biography
Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells by Tsou LK1, Yount JS2, Hang HC3.(PubMed)
(2) Effect of Catechins, Green tea Extract and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria by Fazly Bazzaz BS1, Sarabandi S2, Khameneh B3, Hosseinzadeh H4.(PubMed)
(3) Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa by Radji M1, Agustama RA, Elya B, Tjampakasari CR.(PubMed)
(4) Common bacterial skin infections by Trent JT1, Federman D, Kirsner RS(PubMed)