Carbuncle is a collection of boils developed under the skin caused by bacterial infection of hair follicles in the induction of swelling.
Although the infections are most likely developing on the follicles of the hair, they can also appear on other areas of the body such as the buttocks, thighs, groin, and armpits.
Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.
In the searching of the natural ingredient to replace the use of antibiotics in treatment of bacterial infection of carbuncle, researchers at the J the Rockefeller University found that epigallocatechin-3-gallate isolated from green tea extracts exerts a significant effect iinhibitinged the activity of Staphylococcus aureus (S. aureus), a leading candidate in exhibited risk of carbuncle.
Further analysis also suggested that application EGCG inhibited the typhimurium type III protein effectors in restriction of bacterial invasion into tested cells.
Some researchers at the Mashhad University of Medical Sciences, after lenghty searching for effective agent without inducing intolerant adverse effect for treatment of bacterial infection, found that green tea catechins, the major green tea polyphenols, shows antimicrobial activity against resistant pathogens, including Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa).
In compared of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates, inhibited bacterial activities by a minimum inhibitory concentration (MICs) of gentamicin in the range of 0.312 - 320 μg/mL and The MIC values of both types of catechins were 62.5 - 250 μg/ mL. in compared to no effect in methylxanthines application.
* The inhibition zone diameters of green tea extracts for S. aureus ATCC 25923 and MRSA were 18.970 ± 0.287 mm, and (19.130 ± 0.250) mm respectively.
* The inhibition zone diameter for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were (17.550 ± 0.393) mm and (17.670 ± 0.398) mm respectively.
*The MIC of green tea extracts against S. aureus ATCC 25923 and MRSA were 400 µg/mL and 400 µg/mL, respectively.
* The MIC for P. aeruginosa ATCC 27853 and MDR-P. aeruginosa were 800 µg/mL, and 800 µg/mL, respectively.
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Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Epigallocatechin-3-gallate inhibits bacterial virulence and invasion of host cells by Tsou LK1, Yount JS2, Hang HC3.(PubMed)
(2) Effect of Catechins, Green tea Extract and Methylxanthines in Combination with Gentamicin Against Staphylococcus aureus and Pseudomonas aeruginosa: - Combination therapy against resistant bacteria by Fazly Bazzaz BS1, Sarabandi S2, Khameneh B3, Hosseinzadeh H4.(PubMed)
(3) Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa by Radji M1, Agustama RA, Elya B, Tjampakasari CR.(PubMed)
(4) Common bacterial skin infections by Trent JT1, Federman D, Kirsner RS(PubMed)