Monday, 10 September 2018

The Kitchen Herbal Cayenne Spice Bioactive Compound Which Has The Potential to Cure Non Allergic Rhinitis

By Kyle J. Norton

Scientists may have a positive and potential effect in reduced risk and treatment of  Non Allergic Rhinitis, according to some studies.

Nonallergic rhinitis is a condition with symptoms resemble to allergy induced rhiitis but without a known cause.  However, some researchers suggested that environment pollutants or odors, certain foods or beverages,,,,,,, and  changes in the weather can trigger symptoms of the condition.

Some medications and underlying chronic health problems are associated to increased risk of  nonallergic rhinitis,

Most common symptoms are persistent sneezing, congestion, or runny nose.

Chronic forms of rhinitis occurred in the absence of any detectable specific IgE against relevant allergens. In its broadest sense can be called chronic nonallergic rhinitis(1).

Long term intake of  medicine used for treatment of nonallergic rhinitis such as, nasal sprays containing an antihistamine may reduce symptoms of nonallergic rhinitis but can facilitate side effects of drowsiness or sleepiness, dizziness, dry mouth, nose, or throat,,,,increased appetite, weight gain and upset stomach

In some cases, patients may experience, thickening of mucus, changes in vision, some psychological symptoms of nervousness, excited,... and irritable.

Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belongings to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.

The herb has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.

The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid,.... and palmitic acid.

ICX72 or Sinus Buster, a proprietary homeopathic preparation of Capsicum annum, in the study of 42 consented subjects meeting inclusion/exclusion criteria randomized to ICX72 (n = 20) or control (n = 22) administered twice daily over 2 weeks, exhibited significant differences in changes from baseline and improvement in nasal congestion, sinus pain, sinus pressure, and headache, at 5, 10, 15, and 30 minutes, persisting at 60 minutes for nasal congestion and sinus pain inpatients with Nonallergic rhinitis(2).

Further analysis in concerns of the application adverse effects, researchers found that there are no difference between groups in adverse events in compared to placebo.

Dr. Bernstein JA, the lead author said, " ......intranasal capsaicin, when used continuously over 2 weeks, rapidly and safely improves symptoms in rhinitis subjects with a significant NAR component".

More importantly, ICX72 group experienced no rebound congestion or impaired olfaction in compared to placebo at the end of the study.

Moreover,  in the study of 30 patients randomized into two different treatment regimens
* Group A received capsaicin five times on the first day at 1-h intervals, followed by a placebo dummy once every second or third day for a total of five treatments 2 weeks after the capsaicin application.

* Group B received the placebo dummy five times on the first day followed by capsaicin once every second or third day for a total of five treatments 2 weeks after the placebo application.

At the end of experiment, researchers showed that
* Treatment group A reduced overall nasal symptoms, rhinorrhea and nasal blockage, in compared to group B

* Both groups showed a significant reduction in cold dry air dose responsiveness and nasal hyperreactivity. up to 9 months after therapy

* There were no No significant changes in safety data (smell, blood pressure, heart rate in group A in compared to group B.

Dr. Van Rijswijk JB, the lead scientist wrote, "....intranasal capsaicin seems safe to use and that five treatments of capsaicin on a single day is at least as effective as five treatments of capsaicin in 2 weeks".

The findings suggested that capsaicin may process the potential to cure non allergic rhinitis.

However, large example  size and multi centers clinical trials are necessary to reconfirm capsaicin anti non allergic rhinitis validity.

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Kyle J. Norton(Scholar, Master of Nutrition), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Nonallergic rhinitis by Lieberman P1, Pattanaik D.(PubMed)
(2) A randomized, double-blind, parallel trial comparing capsaicin nasalspray with placebo in subjects with a significant component of nonallergicrhinitis by Bernstein JA1, Davis BP, Picard JK, Cooper JP, Zheng S, Levin LS.(PubMed)
(3) Intranasal capsaicin reduces nasal hyperreactivity in idiopathic rhinitis: a double-blind randomized application regimen study by Van Rijswijk JB1, Boeke EL, Keizer JM, Mulder PG, Blom HM, Fokkens WJ.(PubMed)