Wednesday, 26 September 2018

Herbal Aloe Vera, The Functional Herb Blocks Insulin Resistance Against Onset of Type II Diabetes

By Kyle J. Norton, Master of Nutrition

Herbal Aloe Vera may have a potential effect in lowering insulin resistance, the main cause of type II diabetes, some scientists suggested

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol.

In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

According to the statistic provided by the International Diabetes Federation, 425 million people have diabetes in the world and 159 million people in the western Pacific Region.

Sadly, according to the prediction, by 2045 people infected by diabetes will rise to 183 million.

There were over 3.492.600 cases of diabetes in Malaysia in 2017.

Type 1 diabetes is a condition caused by the immune system mistakenly attacks and destroys the insulin-producing beta cells of the pancreas. 

The actual causes of type 2 diabetes are unknown. However, researchers do know that genetic mutation and unhealthy diet and lifestyle are major risk factors of insulin resistance, the most common cause of type 2 diabetes.

Lisa M. Leontis RN, ANP-C and Amy Hess-Fischl in the article explaining Type 2 Diabetes Causes -
Genetics and Lifestyle Choices Play a Role wrote, " Two people have the same genetic mutation. One of them eats well, watches their cholesterol, and stays physically fit, and the other is overweight (BMI greater than 25) and inactive. The person who is overweight and inactive is much more likely to develop type 2 diabetes because certain lifestyle choices greatly influence how well your body uses insulin".

These results suggested that by keeping your body fit and active accompanied with a healthy diet, one can totally prevent the onset of insulin resistance, the main cause of type 2 diabetes, regardless of other risk factors.

Aloe Vera is species of succulent plant in the genus Aloe, belongings to the Family Xanthorrhoeaceae, native to Sudan cultivated around the world in suitable climate region for commercial profits due to its health benefits.

Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated of cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results

The Ingredients The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

In the study of PCOS induced in Charles Foster female rats by oral administration of non-steroidal aromatase inhibitor letrozole (0.5 mg/kg body weight, 21 days), before administration of herbal Aloe vera, researchers found that all rats exhibits hyperglycemic and 90% of them also showed elevated plasma triglycerides, elevated LDL cholesterol levels, and lowered plasma HDL cholesterol levels indicative of a dyslipidemic profile.

After injection of An AVG formulation (1 ml (10 mg)/day, 30 days) orally, in selected rats with PCOS positive rats with an aberrant lipid profile, researchers showed that* AVG treated PCOS rats exhibited significant reduction in plasma triglyceride and LDL cholesterol levels, with an increase in HDL cholesterol.

* The gel treatment also caused reversion of abnormal estrous cyclicity, glucose intolerance, and lipid metabolizing enzyme activities, bringing them to normal. 

These results suggested that AVG processes phyto components with anti-hyperlipidemic effects and it has shown efficacy in the management of not only PCOS but also the associated metabolic complication of dyslipidemia.

Further to confirm Aloe vera anti-insulin resistance effect induction of type 2 diabetes, researchers at the University of Exeter conducted a review of literature from the database in MEDLINE, EMBASE, Biosis, and the Cochrane Library.

10 selected studies suggest that oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidemia. 

Topical application of aloe vera was not an effective substance in preventative for radiation-induced injuries. However, the application might be effective for genital herpes and psoriasis.

Moreover, in the animal model to examine the effects of processed Aloe vera gel (PAG) on the course of established diet-induced non-insulin-dependent diabetes mellitus (NIDDM) in C57BL/6J mice fed with high-fat diet.

Before injection of Aloe vera gel (PAG), mice exhibited diet-induced obesity (DIO) with blood glucose levels above 180mg/dl, after administrating PAG for 8 weeks, researchers showed that

* Aloe vera gel (PAG) exerts a strong effect in reduced circulating blood glucose concentrations to a normal level in these DIO mice.

* The administration of PAG significantly decreased plasma insulin.

Additionally, PAG antidiabetic effects were confirmed by intraperitoneal glucose tolerance testing. PAG injection also appeared to lower blood glucose levels by decreasing insulin resistance.

Dr. Kim K, the lead author at the final report, wrote, "the oral administration of PAG prevents the progression of NIDDM-related symptoms in high-fat-diet-fed mice, and suggest that PAG could be useful for treating NIDDM".

Taken together, herbal aloe vera gel may be considered as a functional food in decreased insulin resistance and prevent the onset of type 2 diabetes.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299

(1) Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat Model (PubMed)
(2) Aloe vera: a systematic review of its clinical effectiveness. by Vogler BK, Ernst E.(PubMed)
(3) Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. by Kim K, Kim H, Kwon J, Lee S, Kong H, Im SA, Lee YH, Lee YR, Oh ST, Jo TH, Park YI, Lee CK, Kim K.(PubMed)

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