Andrographis paniculata may be one of the best herb in inhibited pathogens (viruses and bacteria) that cause acute upper respiratory tract infection, including the infection of the nose, sinuses, pharynx or larynx. some researchers suggested.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....
According to the joint study lead by the ilpakorn University in the review of the existence data of the literature and meta-analysis of randomized controlled trials, application of andrographis paniculata exerted a strong implication in the symptomatic treatment of uncomplicated upper respiratory tract infection by measuring the reduction in symptom severity scores.
In a total of 433 patients reported in three trials included in the statistical analysis, patient treated with combination of Andrographis aniculata, Acanthopanax senticosus and Andrographis aniculata alone exhibited a significant improvement of 2.13 points and 10.85 points on the symptom severity score respectively, in compared placebo.
Dr. Poolsup N, the lead author said, "A. paniculata extract alone or in combination with A. senticosus extract may be more effective than placebo and may be an appropriate alternative treatment of uncomplicated acute upper respiratory tract infection".
Furthermore, in the review to prevent the over-prescription of antibiotics and absence from work due to acute upper respiratory tract infection, reseahcers found the A. paniculata is found to be more superior to placebo in alleviating the subjective symptoms of uncomplicated upper respiratory tract infection.
The study also indicated that all review trials scored at least three, out of a maximum of five, for methodological quality on the Jadad scale.
More importantly, the efficacy of A. paniculata in relieving symptoms of uncomplicated upper respiratory tract infection only induced generally mild and infrequent adverse effects.
Moreover, in supporting the Andrographis aniculata's anti upper respiratory tract infection property, a total of 223 patients of both sexes randomized in two groups which received either KalmCold (200 mg/day) or placebo, scientists showed that A. paniculata ameliorates symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise/fatigue and sleep disturbance from day 1 to day 3 of treatment in compared to placebo group.
Additionally, the overall efficacy of extract of Andrographis paniculata was found to be 2.1 times (52.7%) higher than placebo.
Taking together, there is no doubt that Andrographis aniculata has a potency used as therapeutic agent for relieving symptoms and treatment of acute upper respiratory tract infection but intake of large doses and long term intake should be taken with care.
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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Andrographis paniculata in the symptomatic treatment of uncomplicated upperrespiratory tract infection: systematic review of randomized controlled trials by Poolsup N1, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U.(PubMed)
(2) Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy by Coon JT1, Ernst E.(PubMed)
(3) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upperrespiratory tract infection by Saxena RC1, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A.(PubMed)
(4) The Epidemiology of Upper Respiratory Infections at a Tertiary Care Center: Prevalence, Seasonality, and Clinical Symptoms by Christy S. Stover and Christine M. Litwin(Hindawi)