Saturday, 15 September 2018

Andrographis aniculata, The Herbal Remedy Which Blocks Pathogens In Initiated Acute Upper Respiratory Tract Infection, Scientists Say

By Kyle J. Norton, Master of Nutrition

Andrographis paniculata may be one of the best herb in inhibited pathogens (viruses and bacteria) that cause acute upper respiratory tract infection, including the infection of the nose, sinuses, pharynx or larynx. some researchers suggested.

The acute infection is very contagious, anyone who comes to contact with patients may also be infected by inhaling respiratory droplets from coughing or sneezing. 

People who are infected by virus that can be resolved without prescription drugs. However, upper respiratory tract infection caused by bacteria, in most case is treated with antibiotics used such as Penicillin VK(Penicillin V) Amoxicillin and (Amoxil, Moxatag, Trimox) Penicillin.

Due to over use of the medicine, some bacteria have developed antibiotic-resistant in response to these medicines.

Intake of antibiotics may be effective, but they have known to interact with others medicine such as medicine that lower cholesterol, treat  migraine,.... and gout, induce serious side effects such as vomiting,  diarrhea, rash........ and abdominal cramps. 

Some patients may also experience allergic reaction induction of shortness of breath, hives, swelling of lips, face, or tongue, fainting.

If you are treated with such medicine, please make sure you discuss the effects with your doctor.

Furthermore, according to the study of Georgia Regents University, "Acute respiratory tract illnesses are the most frequent illnesses of humans and are an important cause of disability and days lost from school or work. Respiratory infections are an important cause of mortality and hospitalization, particularly in the winter in temperate regions" and " In children less than 5 years of age, they are the leading cause of death. Most acute respiratory infections are caused by viruses and bacteria, including rhinoviruses, respiratory syncytial viruses, adenoviruses, influenza viruses, and parainfluenza viruses"(4).

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belongings to the family Acanthaceae, native to India and Sri Lanka.

The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,....

According to the joint study lead by the ilpakorn University in the review of the existence data of the literature and meta-analysis of randomized controlled trials, application of andrographis paniculata exerted a strong implication in the symptomatic treatment of uncomplicated upper respiratory tract infection by measuring the reduction in symptom severity scores.

In a total of 433 patients reported in three trials included in the statistical analysis, patient treated with combination of Andrographis aniculata, Acanthopanax senticosus and Andrographis aniculata alone exhibited a significant improvement of 2.13 points and 10.85 points on the symptom severity score respectively, in compared placebo.

Dr. Poolsup N, the lead author said, "A. paniculata extract alone or in combination with A. senticosus extract may be more effective than placebo and may be an appropriate alternative treatment of uncomplicated acute upper respiratory tract infection".

Furthermore, in the review to prevent the over-prescription of antibiotics and absence from work due to acute upper respiratory tract infection, reseahcers found the A. paniculata is found to be more superior to placebo in alleviating the subjective symptoms of uncomplicated upper respiratory tract infection.

The study also indicated that all review trials scored at least three, out of a maximum of five, for methodological quality on the Jadad scale.

More importantly, the efficacy of A. paniculata in relieving symptoms of uncomplicated upper respiratory tract infection only induced generally mild and infrequent adverse effects.

Moreover, in supporting the Andrographis aniculata's anti upper respiratory tract infection property, a total of 223 patients of both sexes randomized in two groups which received either KalmCold (200 mg/day) or placebo, scientists showed that A. paniculata ameliorates symptoms of cough, expectoration, nasal discharge, headache, fever, sore throat, earache, malaise/fatigue and sleep disturbance from day 1 to day 3 of treatment in compared to placebo group.

Additionally, the overall efficacy of extract of Andrographis paniculata was found to be 2.1 times (52.7%) higher than placebo.

Taking together, there is no doubt that Andrographis aniculata has a potency used as therapeutic agent for relieving symptoms and treatment of acute upper respiratory tract infection but intake of large doses and long term intake should be taken with care.

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Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Andrographis paniculata in the symptomatic treatment of uncomplicated upperrespiratory tract infection: systematic review of randomized controlled trials by Poolsup N1, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U.(PubMed)
(2) Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy by Coon JT1, Ernst E.(PubMed)
(3) A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmCold) in patients with uncomplicated upperrespiratory tract infection by Saxena RC1, Singh R, Kumar P, Yadav SC, Negi MP, Saxena VS, Joshua AJ, Vijayabalaji V, Goudar KS, Venkateshwarlu K, Amit A.(PubMed)
(4) The Epidemiology of Upper Respiratory Infections at a Tertiary Care Center: Prevalence, Seasonality, and Clinical Symptoms by Christy S. Stover and Christine M. Litwin(Hindawi)

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